Mirtazapine is a novel antidepressant with a unique pharmacological profile, which is approved in many countries for the treatment of depression. It belongs to the class of noradrenergic and specific serotonergic antidepressants, and numerous studies have shown that it demonstrates a positive tolerability and safety profile. Mirtazapine has proven to be effective in the treatment of depression and may have a role in the treatment of other disorders.
References
- 1 Review of the results from clinical studies on the efficacy, safety and tolerability of mirtazapine for the treatment of patients with major depression . J. Affect. Disord. 51 , 267 – 285 (1998) .
- 2 Mirtazapine: a review of its use in major depression and other psychiatric disorders . CNS Drugs 23 (5) , 427 – 452 (2009) .
- 3 Brown University psychopharmacology update. Your Medication Information . Mirtazapine (2008) .
- 4 Improving medication compliance in patients with depression: use of orodispersible tablets . Adv. Ther. 27 (11) , 785 – 795 (2010) .
- 5 et al. Safety reporting and adverse-event profile of mirtazapine described in randomized controlled trials in comparison with other classes of antidepressants in the acute-phase treatment of adults with depression . CNS Drugs 24 (1) , 35 – 53 (2010) .
- 6 Antidepressants and body weight: a comprehensive review and meta-analysis . J. Clin. Psychiatry 71 (10) , 1259 – 1272 (2010) .
- 7 Safety of mirtazapine: a review . Int. Clin. Psychopharmacol. 10 (Suppl.4) , 37 – 45 (1995) .
- 8 et al. Toxicity of antidepressants: rates of suicide relative to prescribing and non-fatal overdose . Br. J. Psychiat. 196 , 354 – 358 (2010) .
- 9 et al. Mirtazapine versus other antidepressants in the acute-phase treatment of adults with major depression: systematic review and meta-analysis . J. Clin. Psychiat. 69 , 1404 – 1415 (2008) .
- 10 et al. Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis . Lancet 373 , 746 – 758 (2009) .
- 11 et al. Mirtazapine and paroxetine in major depression: a comparison of monotherapy versus their combination from treatment initiation . Eur. Neuropsychopharm. 19 (7) , 457 – 465 (2009) .
- 12 Managing partial or nonresponse: switching, augmentation and combination strategies for major depressive disorder . J. Clin. Psychiatry 70 (Suppl.6) , 16 – 25 (2009) .
- 13 et al. Combination of antidepressant medications from treatment initiation for major depressive disorder: a double-blind randomized study . Am. J. Psychiatry 167 (3) , 281 – 288 (2010) .
- 14 et al. Combining medications to enhance depression outcomes (CO-MED): acute and long-term outcomes of a single-blind randomized study . Am. J. Psychiatry 168 (7) , 1 – 13 (2011) .
- 15 et al. Two randomized placebo-controlled trials to evaluate the efficacy and tolerability of mirtazapine for the treatment of obstructive sleep apnea . Sleep 31 (6) , 824 – 831 (2008) .
- 16 Treatment of sleep dysfunction and psychiatric disorders . Curr. Treat. Options Neurol. 8 , 367 – 375 (2006) .
- 17 et al. More evidence on proneurocognitive effects of add-on mirtazapine in schizophrenia . Prog. Neuropsychopharmacol. Biol. Psychiatry 35 (4) , 1080 – 1086 (2011) .
- 18 et al. Mirtazapine augmentation for selective serotonin reuptake inhibitor-induced sexual dysfunction: a retrospective investigation . Psychiatry Investig. 8 , 55 – 57 (2011) .
- 19 Mirtazapine: only for depression? Acta Neuropsychiatrica 18 , 130 – 143 (2006) .
- 20 et al. Add-on mirtazapine improves depressive symptoms in schizophrenia: a double-blind randomized placebo-controlled study with an open-label extension phase . Hum. Psychopharmacol. doi:10.1002/hup.1189 (2011) (Epub ahead of print) .
- 21 Depression in children and adolescents . Clin. Evidence 7 , 307 – 313 (2002) .
- 22 Clinical pharmacokinetics of mirtazapine . Clin. Pharmacokinet. 38 (6) , 461 – 474 (2000) .
- 23 Treatment of depression in patients with epilepsy . Curr. Treat. Options Neurol. 13 (4) , 371 – 391 (2011) .
- 24 et al. Mirtazapine and breastfeeding: maternal and infant plasma levels . Am. J. Psychiatry 164 , 348 – 349 (2007) .
- 25 et al. Double-blind, randomized comparison of mirtazapine and paroxetine in elderly depressed patients . Am. J. Geriatr. Psychiatry 10 (5) , 541 – 550 (2002) .
Website
- 101 Merck. Mirtazapine: drug information provided by Lexi-Comp. www.merck.com/product/usa/pi_circulars/r/remeron/remerontablets_pi.pdf