Aryloxy Phosphoramidate Triesters as Pro-Tides
We herein describe the development of aryloxy phosphoramidate triesters as an effective pro-tide motif for the intracellular delivery of charged bio-active antiviral nucleoside monophosphates. The review covers the discovery of such aryl phosphoramidates, their mechanism of action and structure-activity relationships. The application of this strategy to a range of antiviral nucleosides is highlighted.
Keywords: nucleotide; phosphoramidate; pro-drug
Document Type: Review Article
Affiliations: Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK.
Publication date: 01 May 2004
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