Skip to main content
Log in

Constipation in the Elderly

Management Strategies

  • Review Article
  • Published:
Drugs & Aging Aims and scope Submit manuscript

Abstract

Constipation is a highly prevalent and bothersome disorder that negatively affects patients’ social and professional lives and places a great economic burden on both patients and national health services. An accurate determination of the prevalence of constipation is difficult because of the various definitions used, but many epidemiological studies have shown that it affects up to 20% of the population at any one time. Although constipation is not a physiological consequence of normal aging, decreased mobility and other co-morbid medical conditions may contribute to its prevalence in older adults. Functional constipation is diagnosed when no secondary causes can be identified.

Patients have some unusual beliefs about their bowel habits. Systematic attention to history, examination and investigation, especially in older people, can be highly effective in resolving problems and in enhancing quality of life.

There is a considerable range of treatment modalities available for patients with constipation, but the clinical evidence supporting their use varies widely. However, if constipation is not managed proactively, patients can experience negative consequences, such as anorexia, nausea, bowel impaction or bowel perforation.

The clinical benefits of various traditional pharmacological and non-pharmacological agents remain unclear. The first steps in the treatment of simple constipation include increasing intake of dietary fibre and the use of a fibre supplement. Patients with severe constipation or those unable to comply with the recommended intake of fibre may benefit from the addition of laxatives. More recently, newer agents (e.g. tegaserod and lubiprostone), have been approved for the treatment of patients with chronic constipation. Additional work is needed to determine what role, if any, these agents may play in the treatment of patients with chronic constipation.

The purpose of this review is to identify evidence-based interventions for the prevention and management of constipation in the elderly.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Table I
Table II
Table III

Similar content being viewed by others

References

  1. Glia A, Lindberg G. Quality of life in patients with different types of functional constipation. Scand J Gastroenterol 1997; 32: 1083–9

    Article  PubMed  CAS  Google Scholar 

  2. Wald A, Scarpignato C, Mueller-Lissner S, et al. A multinational survey of prevalence and patterns of laxative use among adults with self-defined constipation. Aliment Pharmacol Ther 2008; 28(7): 917–30

    PubMed  CAS  Google Scholar 

  3. Johanson JF, Sonnenberg A, Koch TR. Clinical epidemiology of chronic constipation. J Clin Gastroenterol 1989; 11: 525–36

    Article  PubMed  CAS  Google Scholar 

  4. Johanson JF. Geographic distribution of constipation in the United States. Am J Gastroenterol 1998; 93: 188–91

    Article  PubMed  CAS  Google Scholar 

  5. Singh G, Kahler K, Bharathi V, et al. Adults with chronic constipation have significant health care resource utilization costs of care [abstract no. 701]. Am J Gastroenterol 2004; 99: S227

    Google Scholar 

  6. McCormick A, Fleming D, Charlton J. Morbidity statistics from general practice: fourth national study. London: OPCS, 1995

    Google Scholar 

  7. Sonnenberg A, Koch TR. Physician visits in the United States for constipation: 1958 to 1986. Dig Dis Sci 1989; 34: 606–11

    Article  PubMed  CAS  Google Scholar 

  8. Drossman DA, Li Z, Andruzzi E, et al. US householder survey of functional gastrointestinal disorders: prevalence, socio-demography, and health impact. Dig Dis Sci 1993; 38: 1569–80

    Article  PubMed  CAS  Google Scholar 

  9. Longstreth GF, Thompson WG, Chey WD, et al. Functional bowel disorders and functional abdominal pain. Gastroenterology 2006; 130: 1480–91

    Article  PubMed  Google Scholar 

  10. Herz MJ, Kahan E, Zalevski S, et al. Constipation: a different entity for patients and doctors. Fam Pract 1996; 13: 156–9

    Article  PubMed  CAS  Google Scholar 

  11. Koch A, Voderholzer WA, Klauser AG, et al. Symptoms in chronic constipation. Dis Colon Rectum 1997; 40: 902–6

    Article  PubMed  CAS  Google Scholar 

  12. Higgins PDR, Johanson JF. Epidemiology of constipation in North America: a systematic review. Am J Gastroenterol 2004; 99: 750–9

    Article  PubMed  Google Scholar 

  13. Locke III GR, Pemberton JH, Phillips SF. AGA technical review on constipation. Gastroenterology 2000; 119:1761–78

    Article  PubMed  Google Scholar 

  14. American Gastroenterological Association Medical Position Statement: guidelines on constipation. Gastroenterology 2000; 119: 1761–78

    Google Scholar 

  15. Hsieh C. Treatment of constipation in older adults. Am Fam Physician 2005; 72: 2277–84

    PubMed  Google Scholar 

  16. Allan L, Hays H, Jensen NH, et al. Randomized crossover trial of transdermal fentanyl and sustained release oral morphine for treating chronic non-cancer pain. BMJ 2001; 7295: 1154–8

    Article  Google Scholar 

  17. Radbruch L, Sabatowsk R, Loick G, et al. Constipation and the use of laxatives: a comparison between transdermal fentanyl and oral morphine. Palliat Med 2000; 14(2): 111–9

    Article  PubMed  CAS  Google Scholar 

  18. Folden SL. Practice guidelines for the management of constipation in adults. Rehabil Nurs 2002; 27(5): 169–75

    Article  PubMed  Google Scholar 

  19. Rao SS. Constipation: evaluation and treatment. Gastroenterol Clin North Am 2003; 32: 659–83

    Article  PubMed  Google Scholar 

  20. Hunt R, Lacy B. Diagnosis and management of chronic constipation in the primary care setting. Int Med World Rep 2004; 1 (Suppl.): 3–23

    Google Scholar 

  21. Lembo A, Camilleri M. Chronic constipation. N Engl J Med 2003; 349: 1360–8

    Article  PubMed  CAS  Google Scholar 

  22. Muller-Lissner SA. Effect of wheat bran on weight of stool and gastrointestinal transit time: a meta-analysis. Br J Clin Res Educ 1988; 296: 615–7

    Article  CAS  Google Scholar 

  23. Brandt LJ, Schoenfeld P, Prather CM, et al. Evidence-based position statement on the management of chronic constipation in North America. Am J Gastroenterol 2005; 100 (Suppl.): S1–21

    Article  Google Scholar 

  24. Ramkumar D, Rao SS. Efficacy and safety of traditional medical therapies for chronic constipation: systematic review. Am J Gastroenterol 2005; 100: 936–71

    Article  PubMed  Google Scholar 

  25. Kenny KA, Skelly JM. Dietary fiber for constipation in older adults: a systematic review. Clin Effectiveness Nurs 2001; 5: 120–8

    Article  Google Scholar 

  26. Lindeman RD, Romero LJ, Liang HC, et al. Do elderly persons need to be encouraged to drink more fluids? J Gerontol A Biol Sci Med Sci 2000; 55: M361–5

    Article  PubMed  CAS  Google Scholar 

  27. Lederle FA. Epidemiology of constipation in elderly patients: drug utilization and cost-containment strategies. Drugs Aging 1995; 6: 465–9

    Article  PubMed  CAS  Google Scholar 

  28. Chin A, Paw MJ, van Poppel MN, et al. Effects of resistance and functional skills training on habitual activity and constipation among older adults living in long-term care facilities: a randomized controlled trial. BMC Geriatr 2006; 6: 1–9

    Article  Google Scholar 

  29. Simmons SF, Schnelle JF. Effects of an exercise and scheduled-toileting intervention on appetite and constipation in nursing home residents. J Nutr Health Aging 2004; 8(2): 116–21

    PubMed  CAS  Google Scholar 

  30. Petticrew M, Watt I, Sheldon T. Systematic review of the effectiveness of laxatives in the elderly. Health Technol Assess 1997; 1(13): i–iv, 1–52

    PubMed  CAS  Google Scholar 

  31. Petticrew M, Rodgers M, Booth A. Effectiveness of laxatives in adults. Qual Health Care 2001; 10: 268–73

    Article  PubMed  CAS  Google Scholar 

  32. Mihaylov S, Stark C, McColl N, et al. Stepped treatment of older adults on laxatives: the STOOL trial. Health Technol Assess 2008 May; 12(13): iii–iv, IX-139

    PubMed  CAS  Google Scholar 

  33. Tramonte SM, Brand HB, Mulrow CD, et al. The treatment of chronic constipation in adults: a systematic review. J Gen Intern Med 1997; 12: 15–24

    Article  PubMed  CAS  Google Scholar 

  34. Attar A, Leman M, Ferguson A, et al. Comparison of a low dose of polyethylene glycol electrolyte solution with lactulose for treatment of chronic constipation. Gut 1999; 44: 226–30

    Article  PubMed  CAS  Google Scholar 

  35. Cash BD, Lacy BE. Systematic review: FDA-approved prescription medications for adults with constipation. Gastroenterol Hepatol 2006; 2: 736–49

    Google Scholar 

  36. Christie AH, Culbert P, Guest JF. Economic impact of low-dose polyethylene glycol 3350 plus electrolytes compared with lactulose in the management of idiopathic constipation in the UK. Pharmacoeconomics 2002; 20(1): 49–60

    Article  PubMed  Google Scholar 

  37. Muller-Lissner SA, Kamm MA, Scarpignato C, et al. Myths and misconceptions about chronic constipation. Am J Gastroenterol 2005; 100: 232–42

    Article  PubMed  Google Scholar 

  38. Passmore AP, Wilson-Davies K, Stoker C, et al. Chronic constipation in long-stay elderly patients: a comparison of lactulose and a senna-fibre combination. BMJ 1993; 307: 769–71

    Article  PubMed  CAS  Google Scholar 

  39. Kellemer D, Johanson J, Pobimer B, et al. Alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist: a study in patients with chronic idiopathic constipation (CIC) not taking opioid medications [abstract no. 1239]. Am J Gastroenterol 2006; 101: S480

    Google Scholar 

  40. Thomas J, Karver S, Codney GA, et al. Methylnaltrexone for opioid-induced constipation in advanced illness. N Engl J Med 2008; 358(22): 2332–43

    Article  PubMed  CAS  Google Scholar 

  41. Camilleri M, Kerstens R, Rykx A, et al. A placebo-controlled trial of prucalopride for severe chronic constipation. N Engl J Med 2008; 358(22): 2344–54

    Article  PubMed  CAS  Google Scholar 

  42. Moss AJ. The long and short of a constipation-reducing medication. N Engl J Med 2008; 358(22): 2402–3

    Article  PubMed  CAS  Google Scholar 

  43. Winnepenney JP. Lubiprostone. Drugs 2005; 8: 416–22

    Google Scholar 

Download references

Acknowledgements

No sources of funding were used to assist in the preparation of this review. The authors have no conflicts of interest that are directly relevant to the content of this review.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Giancarlo Spinzi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Spinzi, G., Amato, A., Imperiali, G. et al. Constipation in the Elderly. Drugs Aging 26, 469–474 (2009). https://doi.org/10.2165/00002512-200926060-00003

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00002512-200926060-00003

Keywords

Navigation