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Catherine A. Moreau, Saligram P. Bhargav, Hirdesh Kumar, Katharina A. Quadt, Henni Piirainen, Léanne Strauss, Jessica Kehrer, Martin Streichfuss, Joachim P. Spatz, Rebecca C. Wade, Inari Kursula, Friedrich Frischknecht
A unique profilin-actin interface is important for malaria parasite motility
www.plospathogens.org
www.plospathogens.org
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5.3631 0 Td
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(mosquito)Tj
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(the)Tj
-35.9487 -1.2983 Td
(dermis)Tj
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0.83 0.64 0.02 0 k
(12)Tj
0 g
(].)Tj
2.0806 0 Td
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1.474 0 Td
[()4()4()10()6()4()12()12( )12()]TJ
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(\(IMC\),)Tj
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(15)Tj
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2.6475 0 Td
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(substratum)Tj
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([)Tj
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(16)Tj
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(,)Tj
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1.7348 0 Td
(17)Tj
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(])Tj
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(essential)Tj
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-34.4293 -1.2983 Td
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([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(20)Tj
0 g
(].)Tj
1.7404 0 Td
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3.7247 0 Td
(can)Tj
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(exert)Tj
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(forces)Tj
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(on)Tj
1.2756 0 Td
(various)Tj
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(substrates)Tj
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(in)Tj
1.0318 0 Td
(the)Tj
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(range)Tj
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(100)Tj
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(pN,)Tj
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(which)Tj
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1.542 0 Td
(been)Tj
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4.1102 0 Td
[()12()]TJ
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[()-13()14()7()20()]TJ
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(sporozoites)Tj
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(using)Tj
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(traction)Tj
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(force)Tj
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(microscopy)Tj
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(and)Tj
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(optical)Tj
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(traps)Tj
-34.4804 -1.3039 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7347 0 Td
(21)Tj
0 g
(].)Tj
-0.01 Tc
-0.5385 -1.2983 Td
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3.5432 0 Td
(motility)Tj
3.3279 0 Td
(of)Tj
1.0035 0 Td
(the)Tj
1.4513 0 Td
(different)Tj
3.6056 0 Td
(stages)Tj
2.5229 0 Td
(of)Tj
/F9 1 Tf
1.0034 0 Td
[()4()4()10()6()4()12()12( )12()]TJ
/F8 1 Tf
5.074 0 Td
(as)Tj
1.0035 0 Td
(well)Tj
1.7971 0 Td
(as)Tj
1.0035 0 Td
(related)Tj
2.9026 0 Td
(parasites)Tj
3.634 0 Td
(involves)Tj
-33.0687 -1.2982 Td
(unusually)Tj
4.0365 0 Td
(dynamic)Tj
3.6566 0 Td
(and)Tj
1.7121 0 Td
(short)Tj
2.2564 0 Td
(actin)Tj
2.16 0 Td
(filaments)Tj
3.8551 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7121 0 Td
(21)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(].)Tj
3.1634 0 Td
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2.5342 0 Td
(remarkable)Tj
4.6885 0 Td
(properties)Tj
4.2179 0 Td
(are)Tj
1.4287 0 Td
(due)Tj
-35.4215 -1.3039 Td
(to)Tj
1.0147 0 Td
(a)Tj
0.6463 0 Td
(structural)Tj
4.0195 0 Td
(divergence)Tj
4.4901 0 Td
(of)Tj
1.0035 0 Td
(the)Tj
1.4513 0 Td
(parasite)Tj
3.2768 0 Td
(actin)Tj
2.16 0 Td
(from)Tj
2.1827 0 Td
(canonical)Tj
3.9968 0 Td
(actins)Tj
2.5171 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(])Tj
3.2769 0 Td
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(well)Tj
1.7972 0 Td
(as)Tj
1.0034 0 Td
(a)Tj
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(small)Tj
-34.486 -1.2983 Td
(set)Tj
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(of)Tj
1.0035 0 Td
(regulatory)Tj
4.2632 0 Td
(actin-binding)Tj
5.5956 0 Td
(proteins,)Tj
3.685 0 Td
(which)Tj
2.6192 0 Td
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2.2564 0 Td
(have)Tj
2.0352 0 Td
(non-canonical)Tj
5.9301 0 Td
(functions)Tj
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([)Tj
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(26)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(28)Tj
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(].)Tj
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(higher)Tj
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(eukaryotic)Tj
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(cells,)Tj
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5.0739 0 Td
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(26)Tj
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()Tj
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(29)Tj
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(].)Tj
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(30)Tj
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1.7121 0 Td
(31)Tj
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(ookinete)Tj
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(only)Tj
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0.9807 0 Td
[()4()2()6(\r)-2()6()2()]TJ
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[()7()11()20()11()18()12()]TJ
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[()-13()14()7()20()]TJ
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(doi.org/10.13)Tj
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69.9591 663.6472 l
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139.8047 630.652 l
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38.4945 608.6551 m
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180.9071 597.6567 l
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174.6142 575.6598 l
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(de/exzellenz)Tj
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(initiative/zukunft)Tj
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(skonzept)Tj
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(/frontier_de.)Tj
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(\).)Tj
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(LS,)Tj
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(SFB)Tj
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(1129)Tj
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