Tubulointerstitial Nephritis Complicated by Fanconi Syndrome and Renal Tubular Acidosis Associated with three autoimmune diseases

Kumiko Io; Yoko Obata; Tomoya Nishino; Misaki Hirose; Hiroshi Yamashita; Tadashi Uramatsu; Tatsuki Ichikawa; Tomayoshi Hayashi; Atsushi Kawakami; Takashi Taguchi; Shigeru Kohno

doi:10.11343/amn.58.97

CASE REPORT

Tubulointerstitial Nephritis Complicated by Fanconi Syndrome and Renal Tubular Acidosis Associated with three autoimmune diseases

Kumiko Io, Yoko Obata, Tomoya Nishino, Misaki Hirose, Hiroshi Yamashita, Tadashi Uramatsu, Tatsuki Ichikawa, Tomayoshi Hayashi, Atsushi Kawakami, Takashi Taguchi, Shigeru Kohno

Author information

Kumiko Io
Second Department of Internal Medicine, Nagasaki University School of Medicine
Yoko Obata
Second Department of Internal Medicine, Nagasaki University School of Medicine
Medical Education Development Center, Nagasaki University School of Medicine
Tomoya Nishino
Second Department of Internal Medicine, Nagasaki University School of Medicine
Misaki Hirose
Second Department of Internal Medicine, Nagasaki University School of Medicine
Department of Informatics, Nagasaki University School of Medicine
Hiroshi Yamashita
Second Department of Internal Medicine, Nagasaki University School of Medicine
Division of Blood Purification, Nagasaki University School of Medicine
Tadashi Uramatsu
Second Department of Internal Medicine, Nagasaki University School of Medicine
Tatsuki Ichikawa
Department of Gastroenterology and Hepatology, Nagasaki University School of Medicine
Tomayoshi Hayashi
Department of Pathology, Nagasaki University School of Medicine
Atsushi Kawakami
Department of Immunology and Rheumatology, Nagasaki University School of Medicine
Takashi Taguchi
Clinical Laboratory Department, Nagasaki Municipal Medical Center
Shigeru Kohno
Second Department of Internal Medicine, Nagasaki University School of Medicine

Keywords: tubulointerstitial nephritis, primary biliary cirrhosis, Sjögren’s syndrome, Fanconi syndrome, renal tubular acidosis

JOURNAL FREE ACCESS

2013 Volume 58 Issue 3 Pages 97-102

DOI https://doi.org/10.11343/amn.58.97

Details

Abstract

　A 45-year-old woman experiencing back pain showed signs of metabolic acidosis and electrolyte imbalances. The results of blood and urine tests indicated Fanconi syndrome and renal tubular acidosis. An x-ray showed vertebral fractures, which were thought to responsible for the back pain. In addition, the patient had proteinuria and renal dysfunction; therefore, renal biopsy was performed, and tubulointerstitial nephritis (TIN) was diagnosed. While investigating TIN, primary biliary cirrhosis and Sjögren’s syndrome were also detected. She had been previously diagnosed with chronic thyroiditis. We report a rare case of TIN and 3 autoimmune disorders with review of literature.

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