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The Current Scenario of Nature-Derived Cyclopeptides with Anticancer Potential (A Review)

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Abstract

Nature-derived cyclopeptides, a large group of secondary metabolites, are ubiquitously present in nature. Compared to the linear counterparts, cyclopeptides possess structural rigidity, biochemical stability, binding affinity and membrane permeability. Mechanistically, nature-derived cyclopeptides could interfere with various signaling pathways to induce cancer cell death and demonstrated potential in vitro and in vivo efficacy against various cancers including multidrug-resistant forms. Hence, nature-derived cyclopeptides are propitious lead compounds/candidates for developing novel anticancer therapeutic agents. This review attempts to provide a comprehensive summary of the sources, structural diversity, anticancer potential, and mechanisms of action of nature-derived cyclopeptides, covering articles published from 2018 to present.

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  1. Hubei Engineering Research Center for Fragrant Plants, Hubei University of Science and Technology, 437100, Xianning, China

    B.-s. Liu, K. Liu & Y.-m. Shi

  2. School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, 437100, Xianning, China

    B.-s. Liu, K. Liu, J. Wang & Y.-m. Shi

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Liu, Bs., Liu, K., Wang, J. et al. The Current Scenario of Nature-Derived Cyclopeptides with Anticancer Potential (A Review). Russ J Gen Chem 94, 675–689 (2024). https://doi.org/10.1134/S1070363224030198

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