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Synthesis of secondary propargyl alcohols from aromatic and heteroaromatic aldehydes and acetylene in the system KOH-H2O-DMSO

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Abstract

Ethynylation of aromatic and heteroaromatic aldehydes with acetylene under atmospheric pressure in the catalytic system KOH-H2O-DMSO (aldehyde-KOH molar ratio 1 : 2, −5 to −7°C, 3 h) gave secondary propargyl alcohols in 46–67% yield.

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Authors and Affiliations

  1. Favorskii Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, ul. Favorskogo 1, Irkutsk, 664033, Russia

    L. N. Sobenina, D. N. Tomilin, O. V. Petrova, A. I. Mikhaleva & B. A. Trofimov

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  1. L. N. Sobenina
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  2. D. N. Tomilin
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  3. O. V. Petrova
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  4. A. I. Mikhaleva
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  5. B. A. Trofimov
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Dedicated to Full Member of the Russian Academy of Sciences I.P. Beletskaya on her jubilee

Original Russian Text © L.N. Sobenina, D.N. Tomilin, O.V. Petrova, A.I. Mikhaleva, B.A. Trofimov, 2013, published in Zhurnal Organicheskoi Khimii, 2013, Vol. 49, No. 3, pp. 369–372.

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Sobenina, L.N., Tomilin, D.N., Petrova, O.V. et al. Synthesis of secondary propargyl alcohols from aromatic and heteroaromatic aldehydes and acetylene in the system KOH-H2O-DMSO. Russ J Org Chem 49, 356–359 (2013). https://doi.org/10.1134/S107042801303007X

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  • DOI: https://doi.org/10.1134/S107042801303007X

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