Case Report

Successful Treatment of Severe Pneumocystis Pneumonia with Clindamycin-Primaquine in an HIV-Negative Patient

Authors: Howard C. Crisp MD, Ian J. Stewart MD, Peter J. Blatz MD, David H. Rice MD, Jason F. Okulicz MD

Abstract

Abstract:Pneumocystis pneumonia is an increasingly recognized threat in non-HIV immunosuppressed patients and is associated with worse outcomes compared to HIV-infected patients. The preferred first line treatment is trimethoprim-sulfamethoxazole; however, second line treatments for those intolerant of this regimen have been primarily studied in patients with acquired immunodeficiency syndrome (AIDS). We report a case of Pneumocystis pneumonia in a 75-year-old man with chronic lymphocytic leukemia (CLL) and a history of sulfa allergy successfully treated with clindamycin-primaquine.

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