SPECIAL ARTICLE
Childhood and Adolescent Depression: A Review of the Past 10 Years. Part I

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ABSTRACT

Objective

To qualitatively review the literature of the past decade covering the epidemiology, clinical characteristics, natural course, biology, and other correlates of early-onset major depressive disorder (MDD) and dysthymic disorder (DD).

Method

A computerized search for articles published during the past 10 years was made and selected studies are presented.

Results

Early-onset MDD and DD are frequent, recurrent, and familial disorders that tend to continue into adulthood, and they are frequently accompanied by other psychiatric disorders. These disorders are usually associated with poor psychosocial and academic outcome and increased risk for substance abuse, bipolar disorder, and suicide. In addition, DD increases the risk for MDD. There is a secular increase in the prevalence of MDD, and it appears that MDD is occurring at an earlier age in successive cohorts. Several genetic, familial, demographic, psychosocial, cognitive, and biological correlates of onset and course of early-onset depression have been identified. Few studies, however, have examined the combined effects of these correlates.

Conclusions

Considerable advances have been made in our knowledge of early-onset depression. Nevertheless, further research is needed in understanding the pathogenesis of childhood mood disorders. Toward this end, studies aimed at elucidating mechanisms and interrelationships among the different domains of risk factors are needed.

REFERENCES (199)

  • N Breslau et al.

    Sex differences in depression: a role for preexisting anxiety

    Psychiatry Res

    (1995)
  • GN Clarke et al.

    Cognitive behavioral group treatment of adolescent depression: prediction of outcome

    Behav Ther

    (1992)
  • RE Dahl et al.

    The dexamethasone suppression test in children and adolescents: a review and a controlled study

    Biol Psychiatry

    (1992)
  • RE Dahl et al.

    Sleep onset in depressed adolescents

    Biol Psychiatry

    (1996)
  • RE Dahl et al.

    EEG sleep in adolescents with major depression: the role of suicidality and inpatient status

    J Affect Disord

    (1990)
  • RE Dahl et al.

    EEG sleep measures in prepubertal depression

    Psychiatry Res

    (1991)
  • RE Dahl et al.

    24-Hour Cortisol measures in adolescents with major depression: a controlled study

    Biol Psychiatry

    (1991)
  • RE Dahl et al.

    The regulation of sleep and growth hormone in adolescent depression

    J Am Acad Child Adolesc Psychiatry

    (1992)
  • MD De Bellis et al.

    Nocturnal ACTH, Cortisol, growth hormone, and prolactin secretion in prepubertal depression

    J Am Acad Child Adolesc Psychiatry

    (1996)
  • GJ Emslie et al.

    Sleep EEG features of adolescents with major depression

    Biol Psychiatry

    (1994)
  • DM Fergusson et al.

    Childhood circumstances, adolescent adjustment, and suicide attempts in a New Zealand birth cohort

    J Am Acad Child Adolesc Psychiatry

    (1995)
  • T Ferro et al.

    Depressive disorders: distinctions in children

    J Am Acad Child Adolesc Psychiatry

    (1994)
  • J Fleming et al.

    The outcome of adolescent depression in the Ontario Child Health Study follow-up

    J Am Acad Child Adolesc Psychiatry

    (1993)
  • JE Fleming et al.

    Epidemiology of childhood depressive disorders: a critical review

    J Am Acad Child Adolesc Psychiatry

    (1990)
  • J Garber et al.

    Cognition, stress, and depression in children and adolescents

    Child Adolesc Psychiatr Clin North Am

    (1992)
  • J Garber et al.

    Recurrent depression in adolescents: a follow-up study

    J Am Acad Child Adolesc Psychiatry

    (1988)
  • B Geller et al.

    Rate and predictors of prepubertal bipolarity during follow-up of 6- to 12-year-old depressed children

    J Am Acad Child Adolesc Psychiatry

    (1994)
  • R Harrington et al.

    Adult outcome of childhood and adolescent depression II. Links with antisocial disorders

    J Am Acad Child Adolesc Psychiatry

    (1991)
  • JB Jensen et al.

    Growth hormone dysregulation in children with major depressive disorder

    J Am Acad Child Adolesc Psychiatry

    (1990)
  • PR Joyce et al.

    Birth cohort trends in major depression: increasing rates and earlier onset in New Zeland

    J Affect Disord

    (1990)
  • J Kashani et al.

    Perceptions of family conflict resolution and depressive symptomatology in adolescents

    J Am Acad Child Adolesc Psychiatry

    (1988)
  • J Kaufman

    Depressive disorders in maltreated children

    J Am Acad Child Adolesc Psychiatry

    (1991)
  • MB Keller et al.

    Course of major depression in non-referred adolescents: a retrospective study

    J Affect Disord

    (1988)
  • RC Kessler et al.

    Sex and depression in the national comorbidity survey: II. Cohort effects

    J Affect Disord

    (1994)
  • C Adrian et al.

    Stress exposure and stress generation in children of depressed mothers

    J Consult Clin Psychol

    (1993)
  • HS Akiskal et al.

    Switching from “unipolar” to bipolar II: an 11-year prospective study of clinical and temperamental predictors in 559 patients

    Arch Gen Psychiatry

    (1995)
  • American Psychiatric Association

    Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV)

    (1994)
  • JC Anderson et al.

    Comorbidity of depression in children and adolescents

  • A Angold et al.

    Depressive comorbidity in children and adolescents. Empirical, theoretical, and methodological issues

    Am J Psychiatry

    (1993)
  • J Appleboon-Fondu et al.

    Depression in adolescents and young adults: polysomnographic and neuroendocrine aspects

    J Affect Disord

    (1988)
  • JR Asarnow et al.

    Depression in child psychiatric inpatients: cognitive and attributional patterns

    J Abnorm Child Psychol

    (1988)
  • JR Asarnow et al.

    Children with schizophrenia spectrum and depressive disorders: a comparative study of premorbid adjustment, onset pattern and severity of impairment

    J Child Psychol Psychiatry

    (1988)
  • JR Asarnow et al.

    Coping strategies, self-perceptions, hopelessness, and perceived family environments in depressed and suicidal children

    J Consult Clin Psychol

    (1987)
  • JR Asarnow et al.

    Mother-child dynamics in early onset depression and childhood schizophrenia spectrum disorders

    Dev Psychopathol

    (1990)
  • JR Asarnow et al.

    Family-expressed emotion, childhood-onset depression, and childhood-onset schizophrenia spectrum disorders: is expressed emotion a nonspecific correlate of child psychopathology or a specific risk factor for depression?

    J Abnorm Child Psychol

    (1994)
  • AT Beck

    Cognitive models of depression

    J Cognit Psychother Int Q

    (1987)
  • J Biederman et al.

    Family-environment risk factors for attention-deficit hyperactivity disorder

    Arch Gen Psychiatry

    (1995)
  • AG Billing et al.

    Children of parents with unipolar depression: a controlled 1-year follow up

    J Abnorm Child Psychol

    (1986)
  • HR Bird et al.

    Estimates of the prevalence of childhood maladjustment in a community survey in Puerto Rico: the use of combined measures

    Arch Gen Psychiatry

    (1988)
  • B Birmaher et al.

    Dexamethasone suppression test in adolescents with major depressive disorder

    Am J Psychiatry

    (1992)
  • Cited by (0)

    This is the fifth in a series of 10-year updates in child and adolescent psychiatry. Topics are selected in consultation with the AACAP Committee on Recertification, both for the importance of new research and its clinical or developmental significance. The authors have been asked to place an asterisk before the five or six most seminal references.

    J. McD.

    This article is dedicated to the memory of our teacher and friend, Dr. Joaquim Puig-Antich. This article was supported in part by NIMH grant MH46894 to Dr. Boris Birmaher. The authors thank Therese Deiseroth and Mary Dulgeroff for their assistance in the preparation of the manuscript.

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