Journal of Biological Chemistry
ENZYME CATALYSIS AND REGULATIONAn Extremely Potent Inhibitor of Xanthine Oxidoreductase: CRYSTAL STRUCTURE OF THE ENZYME-INHIBITOR COMPLEX AND MECHANISM OF INHIBITION*
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Published, JBC Papers in Press, November 5, 2002, DOI 10.1074/jbc.M208307200
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This work was supported by Grants-in-aid 11169231 and 12147208 (to T. N.) for Science Research on Priority Areas, Grant-in-aid 13480212 (to T. N.) for Science Research from the Ministry of Education, Science, Sports and Culture of Japan, and a grant from the Canadian Institutes of Health Research, Institute of Genetics (to E. F. P.).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
The atomic coordinates and the structure factors (code ) have been deposited in the Protein Data Bank, Research Collaboratory for Structural Bioinformatics, Rutgers University, New Brunswick, NJ (http://www.rcsb.org/).
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Both authors contributed equally to the results of this article.
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To whom correspondence and reprint requests may be addressed
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To whom correspondence and reprint requests may be addressed