Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Paper
  • Published:

CR6: A third member in the MyD118 and Gadd45 gene family which functions in negative growth control

Oncogene volume 18, pages 4899–4907 (1999)Cite this article

Abstract

MyD118 and Gadd45 are two related genes which encode for proteins that play important roles in negative growth control, including both growth suppression and apoptosis. A strategy was employed to clone new members of the MyD118 and Gadd45 family of genes. Based on alignment of the deduced amino acid sequences, one cDNA clone was found to encode for the murine homologue of human CR6, originally cloned as an IL-2 immediate-early response gene. The murine and human CR6 proteins were observed to be 97% identical, indicating that CR6 is an evolutionarily conserved protein. Analysis of CR6 expression during hematopoietic cell development associated with growth arrest and apoptotic cell death, upon exposure of hematopoietic cells to a variety of growth arrest and apoptotic stimuli, and in a variety of murine tissues, has revealed that CR6 expression differs significantly from the expression of the related MyD118 and Gadd45 genes. Nevertheless, CR6, like MyD118 and Gadd45, suppressed colony formation of human lung carcinoma H1299 cells. These data suggest that CR6 plays similar, but not identical, roles to MyD118 and Gadd45 in negative control of cell growth.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7

Similar content being viewed by others

References

  • Abdollahi A, Lord KA, Hoffman-Liebermann B and Liebermann DA. . 1991 Oncogene 6: 165–167.

  • Beadling C, Johnson KW and Smith KA. . 1993 Proc. Natl. Acad. Sci. USA 90: 2719–2723.

  • El-Deiry WS, Harper JW, O'Connor PM, Velculescu VE, Canman CE, Jackman J, Pietenpol JA, Burrell M, Hill DE, Wang Y, Wiman KG, Mercer WE, Kastan MB, Kohn KW, Elledge SJ, Kinzler KW and Vogelstein B. . 1994 Cancer Res. 54: 1169–1174.

  • Fornace Jr AJ. . 1992 Annu. Rev. Genet. 26: 507–526.

  • Fornace Jr AJ, Jackman J, Hollander MC, Hoffman-Liebermann B and Liebermann DA. . 1992 Ann. NY Acad. Sci. 663: 139–153.

  • Grana X and Reddy EP. . 1995 Oncogene 11: 211–219.

  • Hoffman-Liebermann B and Liebermann DA. . 1991 Oncogene 6: 903–909.

  • Holbrook NJ, Liu Y, Fornace Jr AJ. . 1996 EXS 77: 273–288.

  • Ip YT and Davis RJ. . 1998 Curr. Opin. Cell. Biol. 10: 205–219.

  • Kearsey JM, Coates PJ, Prescott AR, Warbrick E and Hall PA. . 1995 Oncogene 11: 1675–1683.

  • Krishnaraju K, Nguyen HQ, Liebermann DA and Hoffman B. . 1995 Mol. Cell Biol. 15: 5499–5507.

  • Lau LF and Nathans D. . 1987 Proc. Natl. Acad. Sci. USA 84: 1182–1186.

  • Liebermann DA and Hoffman-Liebermann B. . 1989 Oncogene 4: 583–592.

  • Liebermann DA and Hoffman-Liebermann B. . 1994a Curr. Opin. Hematol. 1: 24–32.

  • Liebermann DA and Hoffman B. . 1994b Stem Cells (Dayt) 12: 352–369.

  • Liebermann DA, Hoffman B and Steinman RA. . 1995 Oncogene 11: 199–210.

  • Lord KA, Abdollahi A, Hoffman-Liebermann B and Liebermann DA. . 1990a Cell Growth Differ. 1: 637–645.

  • Lord KA, Abdollahi A, Thomas SM, DeMarco M, Brugge JS, Hoffman-Liebermann B and Liebermann DA. . 1991 Mol. Cell Biol. 11: 4371–4379.

  • Lord KA, Hoffman-Liebermann B and Liebermann DA. . 1990b Oncogene 5: 387–396.

  • Nguyen HQ, Hoffman-Liebermann B and Liebermann DA. . 1993 Cell 72: 197–209.

  • Selvakumaran M, Liebermann D and Hoffman-Liebermann B. . 1993 Blood 81: 2257–2262.

  • Selvakumaran M, Lin HK, Miyashita T, Wang HG, Krajewski S, Reed JC, Hoffman B and Liebermann D. . 1994a Oncogene 9: 1791–1798.

  • Selvakumaran M, Lin HK, Tjin Tham Sjin R, Reed JC, Liebermann DA and Hoffman B. . 1994b Mol. Cell Biol. 14: 2352–6026.

  • Sherr CJ. . 1994 Cell 79: 551–555.

  • Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM and Fornace Jr AJ. . 1994 Science 266: 1376–1380.

  • Takekawa M and Saito H. . 1998 Cell 95: 521–530.

  • Vairapandi M, Balliet AG, Fornace Jr AJ, Hoffman B and Liebermann DA. . 1996 Oncogene 12: 2579–2594.

  • Zeng YX and El-Deiry WS. . 1996 Oncogene 12: 1557–1564.

  • Zhan Q, Lord KA, Alamo Jr I, Hollander MC, Carrier F, Ron D, Kohn KW, Hoffman B, Liebermann DA and Fornace Jr AJ. . 1994 Mol. Cell Biol. 14: 2361–2371.

  • Zhang H, Xiong Y and Beach D. . 1993 Mol. Cell Biol. 4: 897–906.

Download references

Acknowledgements

This research was supported by National Institute for Health grants 1RO1CA51162 (B Hoffman), 1RO1CA43618 (DA Liebermann). We acknowledge Amgen's support for this work.

Author information

Authors and Affiliations

  1. Fels Institute for Cancer Research and Molecular Biology, and Department of Biochemistry, Temple University School of Medicine, 3307 N. Broad St., Philadelphia, PA 19140, Pennsylvania, USA

    Wei Zhang, Insoo Bae, Kandasamy Krishnaraju, Naiyer Azam, Barbara Hoffman & Dan A Liebermann

  2. Department of Medicine, New York Hospital – Cornell Medical Center, New York, NY 10021, USA

    Wen Fan & Kendall Smith

Authors
  1. Wei Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Insoo Bae
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kandasamy Krishnaraju
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Naiyer Azam
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Wen Fan
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kendall Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Barbara Hoffman
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Dan A Liebermann
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhang, W., Bae, I., Krishnaraju, K. et al. CR6: A third member in the MyD118 and Gadd45 gene family which functions in negative growth control. Oncogene 18, 4899–4907 (1999). https://doi.org/10.1038/sj.onc.1202885

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1202885

Keywords

This article is cited by

Search

Advanced search

Quick links