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Chronic active Epstein–Barr virus infection (CAEBV) successfully treated with allogeneic peripheral blood stem cell transplantation

Bone Marrow Transplantation volume 29, pages 531–533 (2002)Cite this article

Abstract

We report a pediatric case of CAEBV and T cell-based Hodgkin's-like disease successfully treated with allo PBSCT from an HLA-matched sibling. The diagnosis of CAEBV was made from clinical signs and the presence of the EBV genome in PBMC and tumor cells. Conditioning with busulfan (BU) + etoposide (VP16) + cyclophosphamide (CY) was effective and well tolerated. EBV was totally eradicated by 3 months after allo PBSCT. Although she suffered from chronic GVHD of the liver, she has been well and free of disease for 47 months since PBSCT. We suggest allo PBSCT for CAEBV as a potent therapeutic strategy for eradication of the EBV genome and allowing immunological reconstitution.

Bone Marrow Transplantation (2002) 29, 531–533. doi:10.1038/sj.bmt.1703392

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Acknowledgements

We are grateful to Koh Kaneko MD (Department of Pathology, Japan Red Cross Ohmiya Hospital) for his help.

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Authors and Affiliations

  1. Division of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan

    T Taketani, A Kikuchi, J Inatomi, R Hanada, H Kawaguchi, K Ida & K Yamamoto

  2. Division of Infectious Disease, Immunology and Allergy, Saitama Children's Medical Center, Saitama, Japan

    T Oh-ishi

  3. Department of Radiology, Saitama Children's Medical Center, Saitama, Japan

    T Arai

  4. Department of Pathology, Saitama Children's Medical Center, Saitama, Japan

    H Kishimoto

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  1. T Taketani
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  2. A Kikuchi
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  3. J Inatomi
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Taketani, T., Kikuchi, A., Inatomi, J. et al. Chronic active Epstein–Barr virus infection (CAEBV) successfully treated with allogeneic peripheral blood stem cell transplantation. Bone Marrow Transplant 29, 531–533 (2002). https://doi.org/10.1038/sj.bmt.1703392

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