The geometry of carotid arteries, both normal and narrowed, produces flow characteristics that predict the location of atherosclerosis and the site of plaque rupture. A recent study has shown that the upstream carotid plaque undergoes profound biochemical and apoptotic changes that are closely linked to the development of stroke symptoms.
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The author is supported by NIH grant RO1 NS20989.
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Fisher, M. Geometry is destiny for carotid atherosclerotic plaques. Nat Rev Neurol 8, 127–129 (2012). https://doi.org/10.1038/nrneurol.2012.1
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DOI: https://doi.org/10.1038/nrneurol.2012.1
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Secreted proteins from carotid endarterectomy: an untargeted approach to disclose molecular clues of plaque progression
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