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Isolation of novel virus-like sequences associated with human hepatitis

Nature Medicine volume 1, pages 564–569 (1995)Cite this article

Abstract

Two viruses, GB virus A (GBV-A) and GB virus B (GBV-B), were recently identified in the GB hepatitis agent. Human sera containing antibodies that recognize GBV-A and/or GBV-B recombinant proteins were subjected to polymerase chain reaction studies with degenerate oligonucleotides capable of amplifying a segment of the putative helicase genes from GBV-A, GBV-B or hepatitis C virus. Novel sequences related to members of the Flaviviridae were identified in sera from 12 individuals including 4 individuals with hepatitis. The limited nucleotide sequence identity between GBV-A, GBV-B and HCV sequences suggests that a novel virus, tentatively named GB virus C, may be responsible for some cases of non-A, non-B, non-C, non-D, non-E hepatitis.

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Authors and Affiliations

  1. Virus Discovery Group, Experimental Biology Research, Abbott Laboratories, North Chicago, Illinois, 60064, USA

    John N. Simons, Thomas P. Leary, George J. Dawson, Tami J. Pilot-Matias, A. Scott Muerhoff, George G. Schlauder, Suresh M. Desai & Isa K. Mushahwar

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  1. John N. Simons
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  2. Thomas P. Leary
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Simons, J., Leary, T., Dawson, G. et al. Isolation of novel virus-like sequences associated with human hepatitis. Nat Med 1, 564–569 (1995). https://doi.org/10.1038/nm0695-564

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