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Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours

Nature Genetics volume 10, pages 436–444 (1995)Cite this article

Abstract

We recently showed that the 1.7 megabase multiple aberration region (MAR) on human chromosome 12q15 harbours recurrent breakpoints frequently found in a variety of benign solid tumours. We now report a candidate gene within MAR suspected to be of pathogenetical relevance. Using positional cloning, we have identified the high mobility group protein gene HMGI–C within a 175 kilobase segment of MAR and characterized its genomic organization. By FISH analysis, we show the majority of the breakpoints of eight different benign solid tumour types fall within this gene. By Southern blot and 3′–RACE analysis, we demonstrate consistent rearrangements in HMGI–C and/or expression of altered HMGI–C transcripts. These results suggest a link between a member of the HMG gene family and benign solid tumour development.

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Authors and Affiliations

  1. Laboratory for Molecular Oncology, Center for Human Genetics, University of Leuven, and Flanders Institute for Biotechnology, Herestraat 49, Leuven, B-3000, Belgium

    Eric F.P.M. Schoenmakers, Raf Mols, Herman Van den Berghe & Wim J.M. Van de Ven

  2. Center for Human Genetics, University of Bremen, Leobenerstrasse ZHG, Bremen, D-28359, Germany

    Sylke Wanschura & Jörn Bullerdiek

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  1. Eric F.P.M. Schoenmakers
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  5. Herman Van den Berghe
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  6. Wim J.M. Van de Ven
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Schoenmakers, E., Wanschura, S., Mols, R. et al. Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Nat Genet 10, 436–444 (1995). https://doi.org/10.1038/ng0895-436

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