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Protein folding: Sticky N17 speeds huntingtin pile-up

Aggregation of huntingtin protein with an expanded polyglutamine region is enhanced by its 17-residue N-terminal domain, which binds to itself and to the polyglutamine region. This enhancement is inhibited when the N-terminal domain binds to the chaperonin TRiC.

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Figure 1: Model of enhancement of polyQ aggregation by N17.

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Correspondence to Susan W Liebman or Stephen C Meredith.

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Liebman, S., Meredith, S. Protein folding: Sticky N17 speeds huntingtin pile-up. Nat Chem Biol 6, 7–8 (2010). https://doi.org/10.1038/nchembio.279

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