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Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

Nature Medicine volume 6, pages 849–851 (2000)Cite this article

Abstract

Cells from the telomerase knockout mouse immortalize with an approximately ten million-fold greater frequency than human cells. In this commentary, Wright and Shay discuss the implications of this difference between mice and men and its relationship to cancer.

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Acknowledgements

We thank K. Collins, C.J. Sherr and R.A. Weinberg for reviewing the manuscript. J.W.S. is a senior scholar of the Ellison Medical Foundation.

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Authors and Affiliations

  1. Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, 75390-9039, Texas

    Woodring E. Wright & Jerry W. Shay

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  2. Jerry W. Shay
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Wright, W., Shay, J. Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology. Nat Med 6, 849–851 (2000). https://doi.org/10.1038/78592

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