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Functional diversity of helper T lymphocytes

Nature volume 383, pages 787–793 (1996)Cite this article

Abstract

The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and pathological immune responses. Defining the cellular and molecular mechanisms of helper-T-cell differentiation should lead to rational strategies for manipulating immune responses for prophylaxis and therapy.

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Authors and Affiliations

  1. Immunology Research Division, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115, USA

    Abul K. Abbas

  2. Department of Pathology, Washington University School of Medicine, St Louis, Missouri, 63110, USA

    Kenneth M. Murphy

  3. Immunobiology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland, 20892, USA

    Alan Sher

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  1. Abul K. Abbas
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  2. Kenneth M. Murphy
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  3. Alan Sher
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Abbas, A., Murphy, K. & Sher, A. Functional diversity of helper T lymphocytes. Nature 383, 787–793 (1996). https://doi.org/10.1038/383787a0

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