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HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

Nature volume 381, pages 667–673 (1996)Cite this article

Abstract

The β-chemokines MIP-1α, MIP-1β and RANTES inhibit infection of CD4+ cells by primary, non-syncytium-inducing (NSI) HIV-1 strains at the virus entry stage, and also block env-mediated cell–cell membrane fusion. CD4+ T cells from some HIV-1-exposed uninfected individuals cannot fuse with NSI HIV-1 strains and secrete high levels of β-chemokines. Expression of the β-chemokine receptor CC-CKR-5 in CD4+ , non-permissive human and non-human cells renders them susceptible to infection by NSI strains, and allows env-mediated membrane fusion. CC-CKR-5 is a second receptor for NSI primary viruses.

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Authors and Affiliations

  1. The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York, 10016, USA

    Tatjana Dragic, Scott R. Martin, Yaoxing Huang, Charmagne Cayanan, Richard A. Koup, John P. Moore & William A. Paxton

  2. Progenies Pharmaceutical, Inc., Tarrytown, New York, 10591, USA

    Virginia Litwin, Graham P. Allaway, Kirsten A. Nagashima & Paul J. Maddon

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  1. Tatjana Dragic
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  2. Virginia Litwin
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Dragic, T., Litwin, V., Allaway, G. et al. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 381, 667–673 (1996). https://doi.org/10.1038/381667a0

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