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A molecular map of the immune response region from the major histocompatibility complex of the mouse

Abstract

A stretch of 200 kilobases (kb) of DNA from the I region of the mouse major histocompatibility complex has been cloned and characterized. It contains the genes for the biochemically defined class II proteins Eα, Eβ and Aβ. DNA blot analyses suggest that the I region may contain only 6–8 class II genes. Correlation of our molecular map with the genetic map of the I region confines two of the five I subregions, I–J and I–B, to less than 3.4 kb of DNA at the 3′ end of the Eβ gene where a hotspot for recombination has been observed. Indeed, the I–A and I–E subregions may be contiguous. If so, the I–B and I–J subregions are not encoded in the I region between the I–A and I–E subregions.

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Steinmetz, M., Minard, K., Horvath, S. et al. A molecular map of the immune response region from the major histocompatibility complex of the mouse. Nature 300, 35–42 (1982). https://doi.org/10.1038/300035a0

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