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Collapsin response mediator protein-1: A novel invasion-suppressor gene

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Abstract

Numerous genetic changes are associated with metastasis of cancer cells. Previously, we used microarray to identify that collapsin response mediator protein-1 (CRMP-1) was involved in cancer invasion and metastasis. We further characterized that CRMP-1 was a novel invasion-suppression gene. Members of the CRMP gene family are intracellular phosphoproteins involved in the mediation of semaphorin induced F-actin depolymerization and growth cone collapse. The precise mechanism by which CRMP-1 inhibits invasion is not yet clear. However, CRMP-1 transfected cells had fewer filopodia and less Matrigel-invasion abilities. A low expression of CRMP-1 mRNA in lung cancer tissue was significantly associated with advanced disease, lymph node metastasis, early post-operative relapse, and shorter survival. In this article, we reviewed the functions of CRMPs and semaphorins and analyzed the structure and motifs of CRMP-1 by bioinformatics. As such, we hoped to shed further light on the mechanism by which CRMP-1 suppresses the invasion of cancer cells.

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Authors and Affiliations

  1. Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

    Jin-Yuan Shih & Pan-Chyr Yang

  2. National Health Research Institutes, Taipei, Taiwan

    Yuan-Chii G. Lee, Chi-Ying F. Huang & Pan-Chyr Yang

  3. Academia Sinica, Institute of Biomedical Sciences, Taipei, Taiwan

    Shuenn-Chen Yang, Tse-Ming Hong & Pan-Chyr Yang

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  1. Jin-Yuan Shih
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Shih, JY., Lee, YC.G., Yang, SC. et al. Collapsin response mediator protein-1: A novel invasion-suppressor gene. Clin Exp Metastasis 20, 69–76 (2003). https://doi.org/10.1023/A:1022598604565

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