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Bipolar affective disorder, type II, apparently precipitated by donepezil

Published online by Cambridge University Press:  24 November 2010

Chris Collins ,
Bronwyn Copeland  and
Matthew Croucher
Chris Collins*
Affiliation:
Princess Margaret Hospital, Christchurch, New Zealand
Bronwyn Copeland
Affiliation:
Tauranga Hospital, Tauranga, New Zealand
Matthew Croucher
Affiliation:
Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand
*
Correspondence should be addressed to: Dr Chris Collins, Old Age Psychiatrist, Princess Margaret Hospital, PO Box 800, Christchurch, New Zealand. Phone: +64-27-2787593; Fax: +64-3-3377519. Email: chris.collins@cdhb.govt.nz.
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Abstract

There is considerable evidence that pro-cholinergic agents can cause depressed mood. However, there are also published case reports of a rare association between cholinesterase inhibitors and mood elevation in patients with pre-existing major functional psychiatric disorders, or organic disorders other than dementia. This report adds to the literature by describing a case of mood elevation in a patient without pre-existing psychiatric disorder.

Keywords

cholinesterase inhibitorsmania
Type
Case Report
Information
International Psychogeriatrics , Volume 23 , Issue 3 , April 2011 , pp. 503 - 504
Copyright
Copyright © International Psychogeriatric Association 2010

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References

Benazzi, F. (1998). Mania associated with donepezil. International Journal of Geriatric Psychiatry, 13, 813–821.3.0.CO;2-I>CrossRefGoogle ScholarPubMed
Benazzi, F. (1999). Mania associated with donepezil. Journal of Psychiatry and Neuroscience, 24, 468–469.Google ScholarPubMed
Burt, T., Sachs, G. S. and Demopulos, C. (1999). Donepezil in treatment-resistant bipolar disorder. Biological Psychiatry, 45, 959–964.CrossRefGoogle ScholarPubMed
Bymaster, F. P. and Felder, C. C. (2002). Role of the cholinergic muscarinic system in bipolar disorder and related mechanism of action of antipsychotic agents. Molecular Psychiatry, 7, S57–S63.CrossRefGoogle ScholarPubMed
Cummings, J. L. (2000). Cholinesterase inhibitors: a new class of psychotropic compounds. American Journal of Psychiatry, 157, 4–15.CrossRefGoogle ScholarPubMed
Evins, A. E., Demopulos, C., Nierenberg, A., Culhane, M. A., Eisner, L. and Sachs, G. (2008). A double-blind, placebo-controlled trial of adjunctive donepezil in treatment-resistant mania. Bipolar Disorders, 8, 75–80.CrossRefGoogle Scholar
Janowsky, D. S., El-Yousef, M. K., Davis, J. M. and Sekerke, H. J. (1972). A cholinergic-adrenergic hypothesis of mania and depression. Lancet, 2, 632–635.CrossRefGoogle ScholarPubMed
Rao, V. (2008). Donepezil induced hypomania. Journal of Neuropsychiatry and Clinical Neuroscience, 20, 107.CrossRefGoogle ScholarPubMed
Shearman, E. et al. (2006). Changes in cerebral neurotransmitters and metabolites induced by acute donepezil and memantine administrations: a microdialysis study. Brain Research Bulletin, 69, 204–213.CrossRefGoogle ScholarPubMed