Endocrine, metabolic and apical effects of in utero and lactational exposure to non-dioxin-like 2,2′,3,4,4′,5,5′-heptachlorobiphenyl (PCB 180): A postnatal follow-up study in rats
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Abbreviations
AHR
aryl hydrocarbon receptor
ANOVA
one-way analysis of variance
AR
androgen receptor
BMD
benchmark dose
BMDL
lower bound of the 90 % confidence interval of the BMD
BMR
benchmark dose response
bw
body weight
CAR
constitutive androstane receptor
CED
critical effect dose = benchmark dose
CES
critical effect size = benchmark dose response
CV
coefficients of variation
CYP
cytochrome P450
DL
dioxin-like
EFSA
European Food Safety Authority
Emax
maximum efficacy
ER
estrogen receptor
EROD
7-ethoxyresorufin O-deethylase
FSH
follicle stimulating hormone
fT3
free triiodothyronine
fT4
free thyroxine
GD
gestational day
GLP
Good Laboratory Practice
IUL
in utero and lactational
JECFA
Joint FAO/WHO Expert Committee on Food Additives
LH
luteinizing hormone
LOD
limit of detection
MoE
margin of exposure
NDL
non-dioxin-like
NOAEL
no-observable-adverse-effect level
PCB
polychlorinated biphenyl
PCDD/Fs
polychlorinated dibenzo-p-dioxins and furans
PND
postnatal day
PROD
7-pentoxyresorufin O-dealkylase
PXR
pregnane-X receptor
RAR
retinoic acid receptor
RXR
retinoid X receptor
TBG
thyroid-binding globulin
TCDD
2,3,7,8-tetrachlorodibenzo-p-dioxin
TR
thyroid hormone receptor
TRIR
total RNA isolation reagent
TTR
transthyretin
UF
uncertainty factor
UGT
UDP glucuronosyltransferase
Keywords
PCB 180
Non-dioxin-like PCBs
Testosterone
Thyroid hormones
Retinoid
Endocrine disruption
Liver
Cited by (0)
- 1
Equal contribution.
- 2
Current address: Labor and Mine Inspection, Ministry of Work, Grand-Duchy of Luxembourg.
- 3
Current address: Office for Medicine and Pharmacy, BMC, Uppsala University, SE-751 23 Uppsala, Sweden.
© 2021 The Author(s). Published by Elsevier Inc.