Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Oral medicineAssociation between glycemic status and oral Candida carriage in patients with prediabetes
Section snippets
Ethical approval
The study was approved by the research ethics review committee of the Jinnah Postgraduate Medical Center, Karachi, Pakistan. The study was performed in accordance with the Declaration of Helsinki as revised in 2000. It was mandatory for all study participants to have read and signed the consent form before being included in this study.
Inclusion and exclusion criteria
Only individuals with medically diagnosed prediabetes (FBGL, 100-125 mg/dL [5.6-6.9 mmol/L]; hemoglobin A1c [HbA1c], 5.7%-6.4%) were included. Exclusion criteria
Characteristics of the study cohort
Eighty patients with prediabetes (43 patients [38 males and 5 females] in group A and 37 patients [35 males and 2 females] in group B) and 70 controls (61 males and 9 females) were included for study. There was no significant difference in age among participants in groups A (41.2 ± 1.6 years), B (43.1 ± 2.1 years), and C (40.6 ± 1.5 years). The mean duration of prediabetes among participants in groups A and B was 11 ± 2.2 months and 13.2 ± 1.4 months, respectively (Table I).
The mean FBGL was
Discussion
To our knowledge from indexed literature, this is the first study in which oral Candida carriage was investigated in patients with prediabetes with particular emphasis on glycemic status. In general, the population with prediabetes investigated in the present study was hyperglycemic (FBGL, 109.3 ± 4.2 mg/dL; HbA1c, 5.8 ± 0.2%), which is a possible explanation for the increased oral C albicans carriage in patients with prediabetes (n = 80) compared with healthy controls (70 individuals in group
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The authors thank the College of Dentistry Research Center and Deanship of Scientific Research at King Saud University, Saudi Arabia, for funding this research project (Project FR 0072).