ReviewDefault-mode brain dysfunction in mental disorders: A systematic review
Section snippets
The default-mode network
The DMN concept although only first introduced into the published literature in 2001 has rapidly become a central theme in contemporary cognitive and clinical neuroscience. Here we identify five key elements.
Methods and measurement models
In order to understand the findings relating DMN activity to mental disorders reviewed below and so to draw out the relevant and appropriate implications, a survey of key methodological and analytical issues is presented. Resting brain states and the DMN have been principally investigated using fMRI (e.g. Greicius et al., 2003, Greicius et al., 2004, Greicius et al., 2007), although positron emission tomography (PET; e.g. Raichle et al., 2001) and electrophysiology have also been employed (e.g.
Putative mechanisms for default-mode-related dysfunction in mental disorder
DMN abnormalities may take a number of different forms and be implicated in a number of different ways in the pathophysiology of mental disorder. Here we outline some putative mechanisms of potential significance for the study of the causal pathways to mental disorder. All empirical research described in the following section refers to resting state fMRI data unless otherwise stated.
A systematic review of empirical studies of default-mode abnormalities and mental disorders
For this review, computerised searches were conducted using the Nature journals online, PubMed, Proquest 5000, Psycinfo and ScienceDirect databases. The following terms default-mode, resting state, low frequency oscillations, functional connectivity and task-positive network were entered into the databases. Further, the table of contents of journals that often publish articles relevant to this topic were also reviewed including Biological Psychiatry, Human Brain Mapping, Journal of Cognitive
Integration and future directions
In the current paper we have considered the relevance of the DMN in relation to mental disorders. There are a number of important observations that may be drawn from the preceding sections, which have significance for theoretical models of psychopathology and provide directions for future research.
In conclusion
In recent years there has been a surge of scientific interest in resting state brain function and the DMN. This interest has extended to the altered patterns of DMN activity in individuals with mental disorder. In the current paper we have described some putative mechanisms for default-mode related dysfunction in mental disorder and have attempted to draw out the potential significance of these for theoretical models of psychopathology. Future research should now focus on a systematic
References (148)
- et al.
Disruption of large-scale brain systems in advanced aging
Neuron
(2007) - et al.
Default-mode network activity distinguishes amnestic type mild cognitive impairment from healthy aging: a combined structural and resting-state functional MRI study
Neurosci. Lett.
(2008) - et al.
Separating respiratory-variation-related fluctuations from neuronal-activity-related fluctuations in fMRI
NeuroImage
(2006) - et al.
Resting state oscillatory brain dynamics in Parkinson's disease: an MEG study
Clin. Neurophysiol.
(2006) Fourier-, hilbert- and wavelet-based signal analysis: are they really different approaches?
J. Neurosci. Methods
(2004)- et al.
Cingulate-precuneus interactions: a new locus of dysfunction in adult attention-deficit/hyperactivity disorder
Biol. Psychiatry
(2008) - et al.
Varieties of attention-deficit/hyperactivity disorder-related intra-individual variability
Biol. Psychiatry
(2005) - et al.
EEG default mode network in the human brain: spectral regional field powers
NeuroImage
(2008) - et al.
Source separation using single channel ICA
Signal Process.
(2007) - et al.
Single-trial EEG/fMRI reveals the dynamics of cognitive function
Trends Cogn. Sci.
(2006)