Elsevier

Microvascular Research

Volume 144, November 2022, 104419
Microvascular Research

Skin microcirculation in middle-aged men with newly diagnosed arterial hypertension according to remote laser Doppler flowmetry data

https://doi.org/10.1016/j.mvr.2022.104419Get rights and content
Under a Creative Commons license
open access

Highlights

  • In early arterial hypertension (AH) perfusion efficiency in skin is reduced.

  • Neurogenic and myogenic vasomotor tones increase with the development of AH.

  • Pulse oscillations demonstrate the highest correlation with blood pressure.

  • Wrist-mounted LDF monitors are promising for early hypertension monitoring.

Abstract

Objective

This work aims to study the functional state of resistive skin microvessels in patients with newly diagnosed arterial hypertension (AH), using portable laser Doppler flowmetry (LDF) devices.

Materials and methods

The study included 89 men aged 30 to 60 years (44.4 ± 8.5) who had no known medical complaints, subjectively considered themselves healthy, and did not take medications on a regular basis. All the men underwent LDF on the left forearm, daily blood pressure (BP) monitoring (DBPM) on the left arm, echocardiography, and laboratory tests. According to DBPM data, the men were divided into two groups. The control group (CG) consisted of 30 men with normal BP, and 59 men were included in the AH group.

Results

According to LDF data, in men with AH, there is a decrease in the amplitude (tone increase) of neurogenic and myogenic vasomotion, a decrease in the amplitude of pulse oscillations of microcirculatory flow, a decrease in perfusion efficiency of endothelial, neurogenic, myogenic and pulse mechanisms of tissue perfusion regulation. Of all tone-forming mechanisms, only the myogenic mechanism has a weak negative correlation with systolic blood pressure level. The amplitude of pulse oscillations demonstrates the highest degree of correlation with blood pressure parameters.

Conclusion

The functional disorders of vasomotor activity of resistive skin microvessels revealed in men with AH have minor correlations with the level of blood pressure. Despite this, the use of portable devices for remote LDF may be a useful method for the dynamic monitoring of patients with hypertension, which requires further research.

Keywords

Portable laser Doppler flowmetry
VECSEL
Newly diagnosed arterial hypertension
Daily blood pressure monitoring
Echocardiography
Skin blood perfusion
Blood perfusion oscillations
Resistive skin microvessels
Vasomotor activity

Cited by (0)