Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Volume 1853, Issue 5, May 2015, Pages 1130-1144
ReviewCellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease
Under an Elsevier user license
open archive
Graphical abstract
Abbreviations
ABC
ATP-binding cassette
ALAS
δ-aminoleuvulinate synthase
CIA
cytosolic ISC protein assembly
DCYTB
duodenal cytochrome b
DMT1
divalent metal transporter 1
FBXL5
F-box and Leucine-rich Repeat Protein 5
FIH1
factor inhibiting HIF 1
FPN1
ferroportin 1
FTL
L-ferritin
FTH1
H-ferritin
HIF
hypoxia-inducible factor
FDXR
ferredoxin reductase
FDX1/2
ferredoxins 1 and 2
FRDA
Friedreich's ataxia
FTMT
mitochondrial-specific ferritin
GLRX5
glutaredoxin 5
IMM
inner mitochondrial membrane
IRP
iron regulatory protein
IRE
iron responsive element
ISC
iron–sulfur cluster
ISCU
ISC assembly enzyme
KH
K homology
LIP
labile iron pool
LYR
leucine–tyrosine–arginine
LYRM
LYR motif
LYRM4
LYR motif-containing 4
MFRN
mitoferrin
NCOA4
nuclear receptor coactivator 4
NFS1
NFS1 cysteine desulfurase
NTBI
non-transferrin-bound iron
OMM
outer mitochondrial membrane
PCBP
poly (rC)-binding protein
PHD
prolyl-4-hydroxylase domain-containing iron-dependent prolyl hydroxylase
PPIX
protoporphyrin IX
ROS
reactive oxygen species
SDHAF1
succinate dehydrogenase assembly factor 1
SDHB
succinate dehydrogenase subunit B
STEAP3
six trans-membrane epithelial antigen of the prostate 3
Tf
transferrin
TfR1
transferrin receptor 1
UTR
untranslated region
VDAC
voltage-dependent anion channel
VHL
von Hippel–Lindau protein
ZIP
ZRT/IRT-like protein
Keywords
Iron metabolism
Iron uptake
Transferrin
ISC biogenesis
Mitochondrion
Cited by (0)
Copyright © 2015 Elsevier B.V. All rights reserved.