American Journal of Obstetrics and Gynecology
ResearchObstetricsMaternal depressive symptoms, serum folate status, and pregnancy outcome: results of the Amsterdam Born Children and their Development study
Section snippets
Materials and Methods
The present study is part of the Amsterdam Born Children and their Development (ABCD) study. The ABCD study is a prospective birth cohort study examining the associations between pregnancy conditions and the child's health in a multiethnic population (www.abcd-study.nl). Pregnant women from Amsterdam were approached for their participation between January 2003 and March 2004 when they first visited an obstetric care provider. All (12,373) received a questionnaire by post, which was filled out
Results
Following the inclusion criteria, 4044 cases were included in the current study's analyses. In this sample, the first visit to an obstetric care provider and thus determination of serum folate status was around the 14th (IQR, 12th to 15th) week of pregnancy. Population characteristics are presented by depressive symptoms group in Table 1.
The folate status quintiles as used in the analyses were defined by folate status standardized for pregnancy duration at the time of blood collection. The
Comment
In this large population-based cohort, depressive symptoms were associated with shorter gestational age and related lower birthweight. The combination of depressive symptoms and low serum folate status (present in 7.6% of the pregnant women) was associated with a shorter gestation of 2.8 days on average, but there was no significant interaction. The onset of delivery did not influence the results.
To our knowledge, the current study is the first to explore the combined detrimental effect of
Acknowledgments
We kindly thank all participants of the ABCD cohort and their obstetric care providers.
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Continuous supplementation of folic acid in pregnancy and the risk of perinatal depression–A meta-analysis
2022, Journal of Affective DisordersCitation Excerpt :The type of control for each study is shown in Table 5. Five studies reported the folate level of pregnant women (Aishwarya et al., 2013; Blunden et al., 2012; Chong et al., 2014; Van Dijk et al., 2010). The standardized mean difference and 95%CI were used as the effect size for meta-analysis.
Psychosocial and peripartum determinants of postpartum depression: Findings from a prospective population-based cohort. The ABCD study
2021, Comprehensive PsychiatryCitation Excerpt :Detailed information regarding the study design has been published in the cohort profile [34]. Furthermore, the design and measures used for the current study have previously been described in publications of the ABCD study addressing research questions related to maternal psychosocial and obstetric health different from the current aim [35–55]. Preliminary results addressing the main research question of the current study have been published in a conference abstract [56].
Antenatal depression programs cortisol stress reactivity in offspring through increased maternal inflammation and cortisol in pregnancy: The Psychiatry Research and Motherhood – Depression (PRAM-D) Study
2018, PsychoneuroendocrinologyCitation Excerpt :Consistent with this, and with previous research, depressed women in our study do indeed have shorter length of gestation. Previous meta-analyses have also shown an association between antenatal depression and preterm birth (Grote et al., 2010; Grigoriadis et al., 2013), although the evidence for shortened length of gestation per se is mixed (Van Dijk et al., 2010; O’Keane et al., 2011; Grigoriadis et al., 2013). Interestingly, we find no significant correlations between maternal inflammatory biomarkers and shorter length of gestation, while two previous studies did: Blair et al. (2015) found a negative correlation between IL-8 (at 19–30 weeks gestation) and length of gestation, although this finding was only apparent in African American (n = 79), not European American women; and Coussons-Read et al. (2012) found a negative correlation between both IL-6 and TNFα (at 28–30 weeks gestation) and length of gestation in 173 mostly Hispanic women, who were free from psychiatric disorder.
The association of folate and depression: A meta-analysis
2017, Journal of Psychiatric ResearchSocial determinants, prenatal care and postpartum depression: Results from the 2010 National Nutrition Survey: A cross sectional study
2013, Progresos de Obstetricia y Ginecologia
This study was supported in part by The Netherlands Organization for Health Research and Development (ZonMw) and The Netherlands Heart Foundation.
Cite this article as: van Dijk AE, van Eijsden M, Stronks K, et al. Maternal depressive symptoms, serum folate status, and pregnancy outcome: results of the Amsterdam Born Children and their Development study. Am J Obstet Gynecol 2010;203:563.e1-7.