CREB and the formation of long-term memory

doi:10.1016/S0959-4388(96)80082-1

Current Opinion in Neurobiology

Volume 6, Issue 2, April 1996, Pages 264-268

https://doi.org/10.1016/S0959-4388(96)80082-1 Get rights and content

Abstract

Cyclic AMP response element binding protein (CREB)-responsive transcription plays a central role in the formation of long-term memory in Drosophila, Aplysia and mice. Agents that disrupt the activity of CREB specifically block the formation of long-term memory, whereas agents that increase the amount or activity of the transcription factor accelerate the process. These results have led to the recent hypothesis that CREB is pivotal in the switch from short-term (protein synthesis independent) to long-term (protein synthesis dependent) memory.

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CREB and the formation of long-term memory

Abstract

Trends Neurosci

Cell

Cell

Proc Natl Acad Sci USA

Nature

Neuron

Neuron

J Neurosci

Science

Science

Science

Mol Endocrinol

Science

Science

Cell

Protein synthesis and memory: a review

Psychol Bull

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element binding protein

Cell

CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila

Cell

Learning in normal and mutant Drosophila larvae

Science

Defect in cyclic AMP phosphodiesterase due to the dunce mutation of learning in Drosophila melanogaster

Nature

Molecular analysis of cDNA clones and the corresponding genomic coding sequences of the Drosophila dunce+ gene, the structural gene for cAMP phosphodiesterase

Proc Natl Acad Sci USA

Molecular analysis of cDNA clones and the corresponding genomic coding sequences of the Drosophila dunce⁺ gene, the structural gene for cAMP phosphodiesterase