Elsevier

The Lancet

Volume 296, Issue 7684, 5 December 1970, Pages 1149-1153
The Lancet

ASSOCIATION BETWEEN POLYARTERITIS AND AUSTRALIA ANTIGEN

https://doi.org/10.1016/S0140-6736(70)90339-9Get rights and content

Abstract

Four of eleven patients with biopsyproven polyarteritis nodosa were also found to have Australia (Au) antigenæmia. The four Au-antigen-positive patients exhibited a typical polyarteritis syndrome, but differed from the seven antigen-negative patients in that they also had evidence of mild hepatic damage. The presence of circulating immune complexes in the sera of three of the four Au-antigen-positive patients was demonstrated by serological, ultracentrifugal, and electro-microscopic studies. These complexes were further shown to be composed of Au antigen and immunoglobulin. Immunofluorescent studies of tissue from one of the patients revealed deposition of Au antigen, IgM, and β1C in blood-vessel walls.

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A preliminary report of this work was presented to the meeting of the Arthritis and Rheumatism Association in Detroit, Michigan, on June 21, 1970.

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