Elsevier

The Lancet

Volume 356, Issue 9247, 16 December 2000, Pages 2069-2070
The Lancet

Research Letters
Methadone, ciprofloxacin, and adverse drug reactions

https://doi.org/10.1016/S0140-6736(00)03409-7Get rights and content

Summary

Ciprofloxacin, given to a patient successfully treated with methadone for more than 6 years, caused profound sedation, confusion, and respiratory depression. We suggest that this was caused by ciprofloxacin inhibition of CYP1A2 and CYP3A4 activity, two of the cytochrome p450 isozymes involved in the metabolism of methadone.

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