Elsevier

Tetrahedron

Volume 33, Issue 7, 1977, Pages 683-710
Tetrahedron

Tetrahedron report number 27
Synthesis of macrolides

https://doi.org/10.1016/0040-4020(77)80180-4Get rights and content

Abstract

The biologically important macrolide class of natural products, although known for some time, has until recently received little synthetic attention. This was primarily due to the lack of general synthetic methodology and the complex structures involved, but in recent years has changed with the development of new experimental techniques. The recent synthetic advancements in this area, reported from the laboratories of Prof. E.J. Corey of Harvard University were undoubtedly the most powerful single thrust that brought these medicinally useful molecules into focus and propelled them into the forefront of organic synthesis. Following a brief introduction into the macrolide structural spectrum, the general methodology for macrolide synthesis is discussed in detail with several illustrative applications. A number of total syntheses of macrolides is then detailed with particular emphasis on the key macrolide ring-forming reactions.

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