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Cardiac Rhythm Disturbances Associated with Amlodipine Acute Intoxication

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Abstract

Amlodipine is a dihydropyridine calcium channel antagonist extensively used for the treatment of arterial hypertension, with predominant effect on the peripheral vascular territory. In most cases of severe intoxication, important hypotension and reflex tachycardia are usually observed. We report a case of young man with severe amlodipine intoxication that developed important bradyarrhythmias, such as low atrial rhythm, prolonged PR interval, atrioventricular block, and left bundle branch block. These rhythm disturbances suggest that, during acute intoxication, dihydropyridine loses its selective action on the vascular territory and can depress automatism and conduction of cardiac electrical stimulus.

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Authors and Affiliations

  1. Division of Emergency Medicine, Department of Internal Medicine, São Paulo University Medical School at Ribeirão Preto, Rua Bernardino de Campos, 1000, Ribeirão Preto, SP, 14015-130, Brazil

    Carlos Henrique Miranda, Leudo Xavier, Flávio Fiorante, Gustavo Prata Misiara, Ellen Gonçalves Guimarães, Ana Marta Galli, Antônio Pazin-Filho & Marcos de Carvalho Borges

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  1. Carlos Henrique Miranda
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  2. Leudo Xavier
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  3. Flávio Fiorante
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  4. Gustavo Prata Misiara
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  5. Ellen Gonçalves Guimarães
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  6. Ana Marta Galli
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  7. Antônio Pazin-Filho
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  8. Marcos de Carvalho Borges
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Correspondence to Carlos Henrique Miranda.

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Miranda, C.H., Xavier, L., Fiorante, F. et al. Cardiac Rhythm Disturbances Associated with Amlodipine Acute Intoxication. Cardiovasc Toxicol 12, 359–362 (2012). https://doi.org/10.1007/s12012-012-9176-9

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  • DOI: https://doi.org/10.1007/s12012-012-9176-9

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