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One hundred years of Meldrum’s acid: advances in the synthesis of pyridine and pyrimidine derivatives

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Abstract

A general review (138 references) focused on the recent advances in the application of Meldrum’s acid reactivity for synthesis of diverse pyridine and pyrimidine derivatives, mostly small and drug-like molecules is presented.

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Authors and Affiliations

  1. State Institution “V.Ya. Danilevsky Institute of Endocrine Pathology Problems”, Academy of Medical Sciences of Ukraine, Artema St., 10, 61002, Kharkov, Ukraine

    Victoria V. Lipson

  2. Department of Chemistry of Heterocyclic Compounds, State Scientific Institution “Institute for Single Crystals”, National Academy of Sciences of Ukraine, Lenin Avenue, 60, 61001, Kharkov, Ukraine

    Victoria V. Lipson & Nikolay Yu. Gorobets

  3. AG Limbach, Institute for Organic Chemistry, Free University of Berlin, Takustr. 3, 14195, Berlin, Germany

    Nikolay Yu. Gorobets

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Lipson, V.V., Gorobets, N.Y. One hundred years of Meldrum’s acid: advances in the synthesis of pyridine and pyrimidine derivatives. Mol Divers 13, 399–419 (2009). https://doi.org/10.1007/s11030-009-9136-x

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