Abstract
In Brazil, compounded diet pills that combine amphetamines, benzodiazepines, antidepressants, diuretics and laxatives are often prescribed. In 2006, the Food and Drug Administration banned their sale in the United States (US) citing substantial safety concerns. This study evaluates the prevalence of, and factors associated with, use of these pills among Brazilian immigrant women aged 18–50. Pill use was assessed at one clinic and two churches using an anonymous survey (n = 307). While living in the US, 18% of clinic respondents and 9% of church respondents reported using these diet pills. Nearly two thirds of pill users reported adverse effects. In multivariate logistic regression analysis, being unmarried, college educated, dissatisfied with current weight, and advised by a US physician to lose weight were associated with greater odds of imported diet pill use. To enhance care of Brazilian immigrants, US physicians should become familiar with the health consequences of imported diet pills from Brazil.
Similar content being viewed by others
References
Ioannides-Demos LL, Proietto J, Tonkin AM, McNeil JJ. Safety of drug therapies used for weight loss and treatment of obesity. Drug Safety 2006;29:277–302.
Gurtner HP. Aminorex and pulmonary hypertension: a review. Cor Vasa 1985;27:160–71.
Connolly HM, Crary JL, McGoon MD, Hensrud DD, Edwards BS, Edwards WD, Schaff HV. Valvular heart disease associated with fenfluramine-phentermine. N Engl J Med 1997;337:581–8.
Mark EJ, Patalas ED, Chang HT, Evans RJ, Kessler SC. Fatal pulmonary hypertension associated with short-term use of fenfluramine and phentermine. N Engl J Med 1997;337:602–6.
Gardin JM, Schumacher D, Constantine G, Davis KD, Leung C, Reid CL. Valvular abnormalities and cardiovascular status following exposure to dexfenfluramine or phentermine/fenfluramine. JAMA 2000;283:1703–9.
Nortier JL, Martinez MM, Schmeiser HH, Arlt VM, Bieler CA, Petein M, Depierreux MF, DePauw L, Abramowicz D, Vereerstraeten P, Vanherweghem JL. Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi). N Engl J Med 2000;342:1686–92.
Nappo SA, Carlini EA. Países sulamericanos solicitam legislação proibindo fórmulas magistrais e associações medicamentosas para tratamento de obesidade. Boletim Centro Brasileiro de Informações (CEBRID) 1993;12:4.
Bianco A. Perdendo peso e o bom senso. Pesquisa FAPESP. Online edition. Published 6/29/07. Available at http://www.revistapesquisa.fapesp.br.
Nappo SA, de Oliveira EM, Morosini S. A prescrição por médicos brasileiros de fórmulas magistrais para emagrecer : uma duvidosa prática para a saúde dos pacientes. Arquivos Brasileiros de Medicina 1994;68:15–20.
FDA warns consumers about Brazilian diet pills found to contain active drug ingredients. P06–07. Food and Drug Administration, Rockville 2006.
Nappo SA, Tabach R, Noto AR, Galduróz JC, Carlini ES. Use of anorectic amphetamine-like drugs by Brazilian women. Eating Behaviors 2002;3:153–65.
National heart, lung, and blood institute obesity education initiative expert panel on the identification, evaluation, and treatment of overweight and obesity in adults: clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. NIH Publication No. 98–4083. Washington: National Heart, Lung, and Blood Institute; 1998.
National Institute for Health and Clinical Excellence. Obesity: guidance on the prevention, identification, assessment and management of overweight and obesity in adults and children. NICE clinical guide 43. London: National Institute for Health and Clinical Excellence; 2006.
Clinical Pharmacology [database online]. Tampa, FL: Gold Standard, Inc.; 2007. http://www.clinicalpharmacology.com. Accessed Feb 2007.
Olson KR. Poisoning and drug overdose. 5th edn. The McGraw-Hill Companies; 2007.
Mainous AG, Cheng AY, Garr RC, Tilley BC, Everett CJ, McKee MD. Nonprescribed antimicrobial drugs in Latino community, South Carolina. Emerg Infect Dis 2005;11:883–8.
McKee MD, Mills L, Mainous AG. Antibiotic use for the treatment of upper respiratory infections in a diverse community. J Fam Pract 1999;48:993–6.
Taylor L, Abarca S, Henry B, Friedman L. Use of Neo-melubrina, a banned antipyretic drug, in San Diego, California: a survey of patients and providers. West J Med 2001;175:159–163.
Bonkowsky JL, Frazer JK, Buchi KF, Byington CL. Metamizole use by Latino immigrants: a common and potentially harmful home remedy. Pediatrics 2002;109:e98.
Flaskerud JH, Nyamathi AM. Home medication injection among Latina women in Los Angeles: implications for health education and prevention. AIDS Care 1996;8:95–103.
Goel MS, McCarthy EP, Phillips RS, Wee CC. Obesity among US immigration subgroups by duration of residence. JAMA 2004;292:2860–7.
Kaplan MS, Huguet N, Newsom JT, McFarland BH. The association between length of residence and obesity among Hispanic immigrants. Am J Prev Med 2004;27:323–6.
Hosmer D, Lemeshow S. Applied logistic regression. 2nd edn. New York: John Wiley & Sons; 2000.
Ioannides-Demos LL, Proietto J, McNeil JJ. Pharmacotherapy for obesity. Drugs 2005;65:1391–418.
Parran T. Prescription drug abuse: a question of balance. Med Clin N Amer 1997;81:967–78.
Blanck HM, Khan LK, Serdula MK. Prescription weight loss pill use among Americans: patterns of pill use and lessons learned from the fen-phen market withdrawal. Prev Med 2004;39:1243–8.
Nunes MA, Barros FC, Anselmo MT, Camey S, Mari JD. Prevalence of abnormal eating behaviours and inappropriate methods of weight control in young women from Brazil: a population-based study. Eating Weight Disord 2003;8:100–6.
Kruger J, Galuska DA, Serdula MK, Jones DA. Attempting to lose weight: specific practices among U.S. adults. Am J Prev Med 2004;26:402–6.
Breitkopf CR, Berenson AB. Correlates of weight loss behaviors among low-income African-American, Caucasian, and Latina women. Obstet Gynecol 2004;103:231–9.
Bish CL, Blanck HM, Serdula MK, Marcus M, Kohl HW, Khan LK. Diet and physical activity behaviors among Americans trying to lose weight: 2000 behavioral risk factor surveillance system. Obesity Res 2005;13:596–607.
Anderson LA, Eyler AA, Galuska DA, Brown DR, Brownson RC. Relationship of satisfaction with body size and trying to lose weight in a national survey of overweight and obese women aged 40 and older, United States. Prev Med 2002;35:390–6.
Anderson LA, Janes GR, Ziemer DC, Phillips LS. Diabetes in urban African Americans: body image, satisfaction with size and weight change attempts. Diabetes Educ 1997;23:301–8.
Galuska DA, Will JC, Serdula MK, Ford ES. Are health care professionals advising obese patients to lose weight? JAMA 1999;282:1576–8.
Davis C, Katzman MA. Perfection as acculturation: psychological correlates of eating problems in Chinese male and female students living in the United States. Int J Eat Disord 1999;25:65–70.
Al-Subaie AS. Some correlates of dieting behavior in Saudi schoolgirls. Int J Eat Disord 2000;28:242–6.
Pumariega AJ. Acculturation and eating attitudes in adolescent girls: a comparative and correlational study. J Amer Acad Child Psych 1986;25:276–9.
Ayala GX, Mickens L, Galindo P, Elder JP. Acculturation and body image perception among Latino youth. Ethnicity Health 2007;12:21–41.
Borges MB, Jorge MR, Morgan CM, da Silveira DX, Custódio O. Binge-eating disorder in Brazilian women on a weight-loss program. Obesity Res 2002;10:1127–34.
Nappo SA. Consumo de anorexígenos tipo-anfetamina (dietilpropiona, fenproporex, mazindol) e de fenfluramina no Brasil: prejuízo ou benefício para a saúde. J Bras Psiq 1992;41:417–21.
Acknowledgements
We wish to thank the local Brazilian community and the dedicated staff of Somerville Primary Care whose help made this study possible. In addition, we are indebted to Lise Fried, PhD for statistical advice; Juliana Coelho for coordinating the community survey; and Jenny Lee-Olsen for expert research assistance.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Cohen, P.A., McCormick, D., Casey, C. et al. Imported Compounded Diet Pill Use Among Brazilian Women Immigrants in the United States. J Immigrant Minority Health 11, 229–236 (2009). https://doi.org/10.1007/s10903-007-9099-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10903-007-9099-x