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Incidence, Risk Factors and Clinical Course of Pancreatic Fluid Collections in Acute Pancreatitis

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Abstract

Background

Acute pancreatitis is an acute inflammatory process of the pancreas with variable involvement of other regional tissues or remote organ systems. Acute fluid collections and pseudocyst formation are the most frequent complications of acute pancreatitis.

Aims

The aims of this study were to evaluate the incidence, risk factors, and clinical course of pancreatic fluid collections and pseudocyst formation following acute pancreatitis.

Methods

A prospective multicenter study was conducted in five participating centers with 302 patients diagnosed with acute pancreatitis from January 2011 to July 2012.

Results

The incidence of pancreatic fluid collections and pseudocyst was 42.7 and 6.3 %, respectively. Patients with fluid collections were significantly younger, compared to those without fluid collections (51.5 ± 15.9 vs. 60.4 ± 16.5 years, P = 0.000). The proportion of alcoholic etiology (54.3 %) in patients with fluid collections was significantly higher compared to other etiologies (P = 0.000). C-reactive protein (CRP) (48 h) was significantly higher in patients with fluid collections, compared to patients without fluid collections (39.2 ± 77.4 vs. 15.1 ± 36.2 mg/dL, P = 0.016). LDH (48 h) was significantly higher in patients with pseudocyst formation, compared to patients with complete resolution (1,317.6 ± 706.4 vs. 478.7 ± 190.5 IU/L, P = 0.000). Pancreatic fluid collections showed spontaneous resolution in 69.8 % (90/129) and 84.2 % of the pseudocysts disappeared or decreased in size during follow up.

Conclusions

Age, CRP (48 h), and alcohol etiology are risk factors for pancreatic fluid collections. LDH (48 h) appears to be a risk factor for pseudocyst formation. Most pseudocysts showed a decrease in size or spontaneous resolution with conservative management.

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Acknowledgments

This work was supported by the 2011 Yeungnam University Research Grant, and the grant of Research Institute of Medical Science, Catholic University of Daegu (2011).

Conflict of interest

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Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yeungnam University College of Medicine, 317-1 Daemyung 5-dong Nam-gu, Taegu, 705-717, Korea

    Mei Lan Cui, Kook Hyun Kim & Tae Nyeun Kim

  2. Department of Internal Medicine, Catholic University of Daegu School of Medicine, 3056-6 Daemyung 4-dong, Nam-gu, Taegu, 705-718, Korea

    Ho Gak Kim & Jimin Han

  3. Department of Internal Medicine, Daegu Fatima Hospital, 99, Ayangro, Dong-gu, Taegu, 701-600, Korea

    Hyunsoo Kim

  4. Department of Internal Medicine, Keimyung University School of Medicine, 194 Dongsan Dong, Junggu, Taegu, 700-712, Korea

    Kwang Bum Cho

  5. Department of Internal Medicine, Kyungpook National University School of Medicine, 50 Samduck 2-Ga, Jung-gu, Taegu, 700-721, Korea

    Min Kyu Jung & Chang Min Cho

Authors
  1. Mei Lan Cui
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  2. Kook Hyun Kim
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  3. Ho Gak Kim
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  4. Jimin Han
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  5. Hyunsoo Kim
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  7. Min Kyu Jung
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  8. Chang Min Cho
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  9. Tae Nyeun Kim
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Correspondence to Tae Nyeun Kim.

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Cui, M.L., Kim, K.H., Kim, H.G. et al. Incidence, Risk Factors and Clinical Course of Pancreatic Fluid Collections in Acute Pancreatitis. Dig Dis Sci 59, 1055–1062 (2014). https://doi.org/10.1007/s10620-013-2967-4

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  • DOI: https://doi.org/10.1007/s10620-013-2967-4

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