Abstract
Marburg’s variant multiple sclerosis (MS) is an acute and aggressive atypical form of MS, leading frequently to death in few months. A 32-year-old man with motor and sensory symptoms suggestive of acute myelopathy, rapidly followed by cerebellar dysfunction and consciousness impairment. Clinical, laboratory and radiological evaluations suggested a central nervous system demyelinating disease. The diagnosis was Marburg’s variant MS, usually leading to death in short time. He underwent different treatments, including steroids, cyclophosphamide, plasma exchange and lastly interferon-beta. The patient reached clinical stability with severe residual disability, persistent after 3 years from onset. This observation suggests that subjects with Marburg’s MS might reach long clinical stability.
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Turatti, M., Gajofatto, A., Rossi, F. et al. Long survival and clinical stability in Marburg’s variant multiple sclerosis. Neurol Sci 31, 807–811 (2010). https://doi.org/10.1007/s10072-010-0287-4
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DOI: https://doi.org/10.1007/s10072-010-0287-4