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Association of antiphosphatidylserine/prothrombin antibodies with neuropsychiatric systemic lupus erythematosus

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Abstract

Neuropsychiatric manifestations in patients with systemic lupus erythematosus (SLE) are well-recognized symptoms although the pathophysiology of neuropsychiatric SLE (NPSLE) is unclear. Since an association with antiphospholipid antibodies has been reported, we examined the prevalence of antiphosphatidylserine–prothrombin antibodies (anti-PS/PT Abs), lupus anticoagulant (LA), anticardiolipin/β2-glycoprotein I antibodies (anti-β2-GPI Abs), and antiribosomal P protein antibodies (antiribosomal P Abs) in 68 SLE patients and analyzed their associations with neuropsychiatric manifestations. The prevalence of LA was significantly higher in the patients with neuropsychiatric (NP) features than those without NP features (P < 0.02). The levels of anti-PS/PT antibody were also significantly higher in the patients with NP features than those without NP features (P < 0.01). The results indicate that LA positivity and higher levels of anti-PS/PT antibody can be predictive markers for NPSLE.

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Authors and Affiliations

  1. Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan

    Tomoko Syuto, Akira Shimizu, Yuko Takeuchi, Setsuko Tanaka, Michiko Hasegawa, Yayoi Nagai, Atsushi Tamura & Osamu Ishikawa

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  1. Tomoko Syuto
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  2. Akira Shimizu
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  3. Yuko Takeuchi
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  4. Setsuko Tanaka
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  5. Michiko Hasegawa
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  6. Yayoi Nagai
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  7. Atsushi Tamura
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  8. Osamu Ishikawa
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Correspondence to Tomoko Syuto.

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Syuto, T., Shimizu, A., Takeuchi, Y. et al. Association of antiphosphatidylserine/prothrombin antibodies with neuropsychiatric systemic lupus erythematosus. Clin Rheumatol 28, 841–845 (2009). https://doi.org/10.1007/s10067-009-1123-1

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  • DOI: https://doi.org/10.1007/s10067-009-1123-1

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