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Risk factors of vertebral fractures in women with systemic lupus erythematosus

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Abstract

The aim of the current study was to analyze the role of traditional and systemic lupus erythematosus (SLE)-related risk factors in the development of vertebral fractures. A cross-sectional study was performed in women with SLE attending a single center. A vertebral fracture was defined as a reduction of at least 20% of vertebral body height. Two hundred ten patients were studied, with median age of 43 years and median disease duration of 72 months. Osteopenia was present in 50.3% of patients and osteoporosis in 17.4%. At least one vertebral fracture was detected in 26.1%. Patients with vertebral fractures had a higher mean age (50 ± 14 vs. 41 ± 13.2 years, p = 0.001), disease damage (57.1% vs. 34.4%, p = 0.001), lower bone mineral density (BMD) at the total hip (0.902 ± 0.160 vs. 982 ± 0.137 g/cm2, p = 0.002), and postmenopausal status (61.9% vs. 45.3%, p = 0.048). Stepwise logistic regression analysis revealed that only age (p = 0.001) and low BMD at the total hip (p = 0.007) remained as significant factors for the presence of vertebral fracture. The high prevalence of vertebral fractures in the relatively young population implies that more attention must be paid to detect and treat vertebral fractures.

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Authors and Affiliations

  1. Systemic Autoimmune Diseases Research Unit, HGR #36, CMN Manuel Avila Camacho, Instituto Mexicano del Seguro Social, Puebla, Mexico

    Claudia Mendoza-Pinto, Mario García-Carrasco, Mario Jiménez-Hernández & Pamela Munguía-Realpozo

  2. Rheumatology and Immunology Department, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico

    Mario García-Carrasco

  3. Radiology Unit, HGR #36, CMN Manuel Avila Camacho, Instituto Mexicano del Seguro Social, Puebla, Mexico

    Hilda Sandoval-Cruz

  4. State Research and Posgrado, Medicine School Benemérita Universidad Autónoma de Puebla, Puebla, Mexico

    Margarita Muñoz-Guarneros

  5. Internal Medicine, Temple University Hospital, Philadelphia, PA, USA

    Ricardo O. Escárcega

  6. Department of Autoimmune Diseases, Institut Clínic de Medicina i Dermatologia, Hospital Clínic, Villarroel 170, 08036, Barcelona, Catalonia, Spain

    Mario Jiménez-Hernández & Ricard Cervera

  7. Internal Medicine Unit, HGR36, CMN Manuel Avila Camacho, Instituto Mexicano del Seguro Social, Puebla, Mexico

    Manuel Sandoval-Cruz

  8. Osteoporosis Clinic, Hospital Angeles, Puebla, Mexico

    Margarita Delezé-Hinojosa

  9. State Research Departament, Instituto Mexicano del Seguro Social, Puebla, Mexico

    Aurelio López-Colombo

Authors
  1. Claudia Mendoza-Pinto
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  2. Mario García-Carrasco
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  3. Hilda Sandoval-Cruz
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  4. Margarita Muñoz-Guarneros
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  5. Ricardo O. Escárcega
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  6. Mario Jiménez-Hernández
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  7. Pamela Munguía-Realpozo
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  8. Manuel Sandoval-Cruz
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  9. Margarita Delezé-Hinojosa
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  10. Aurelio López-Colombo
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  11. Ricard Cervera
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Corresponding author

Correspondence to Ricard Cervera.

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Mendoza-Pinto, C., García-Carrasco, M., Sandoval-Cruz, H. et al. Risk factors of vertebral fractures in women with systemic lupus erythematosus. Clin Rheumatol 28, 579–585 (2009). https://doi.org/10.1007/s10067-009-1105-3

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  • DOI: https://doi.org/10.1007/s10067-009-1105-3

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