Skip to main content

Advertisement

Log in

Thailand orthohantavirus infection in patients with chronic kidney disease of unknown aetiology in Sri Lanka

  • Brief Report
  • Published:
Archives of Virology Aims and scope Submit manuscript

Abstract

Chronic kidney disease of unknown aetiology (CKDu) reported in Sri Lanka and other countries is a mysterious and serious disease. Recently, we reported a high seroprevalence of antibodies to a hantavirus antigen among CKDu patients in Girandurukotte, Badulla district, Sri Lanka. However, the type of hantavirus with which the residents were infected was not determined. In this study, a total of 89 seropositive sera were examined to identify their serotypes using an indirect immunofluorescent antibody assay, a truncated-N-protein-based enzyme-linked immunosorbent assay, and a cross-neutralization test. These results indicated that the residents in this area were frequently infected with Thailand orthohantavirus or an antigenically related virus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Chandy S, Okumura M, Yoshimatsu K, Ulrich RG, John GT, Abraham P, Arikawa J, Sridharan G (2009) Hantavirus species in India: a retrospective study. Indian J Med Microbiol 27:348–350

    Article  PubMed  CAS  Google Scholar 

  2. de Oliveira RC, Guterres A, Fernandes J, D’Andrea PS, Bonvicino CR, de Lemos ER (2014) Hantavirus reservoirs: current status with an emphasis on data from Brazil. Viruses 6:1929–1973

    Article  PubMed  CAS  Google Scholar 

  3. Elwell MR, Ward GS, Tingpalapong M, LeDuc JW (1985) Serologic evidence of Hantaan-like virus in rodents and man in Thailand. Southeast Asian J Trop Med Public Health 16:349–354

    PubMed  CAS  Google Scholar 

  4. Fulhorst CF, Monroe MC, Salas RA, Duno G, Utrera A, Ksiazek TG, Nichol ST, de Manzione NM, Tovar D, Tesh RB (1997) Isolation, characterization and geographic distribution of Cano Delgadito virus, a newly discovered South American hantavirus (family Bunyaviridae). Virus Res 51:159–171

    Article  PubMed  CAS  Google Scholar 

  5. Gamage CD, Yasuda SP, Nishio S, Kularatne SA, Weerakoon K, Rajapakse J, Nwafor-Okoli C, Lee RB, Obayashi Y, Yoshimatsu K, Arikawa J, Tamashiro H (2011) Serological evidence of Thailand virus-related hantavirus infection among suspected leptospirosis patients in Kandy, Sri Lanka. Jpn J Infect Dis 64:72–75

    PubMed  Google Scholar 

  6. Gamage CD, Yoshimatsu K, Sarathkumara YD, Thiviyaaluxmi K, Nanayakkara N, Arikawa J (2017) Serological evidence of hantavirus infection in Girandurukotte, an area endemic for chronic kidney disease of unknown aetiology (CKDu) in Sri Lanka. Int J Infect Dis 57:77–78

    Article  PubMed  Google Scholar 

  7. Jameson LJ, Taori SK, Atkinson B, Levick P, Featherstone CA, van der Burgt G, McCarthy N, Hart J, Osborne JC, Walsh AL, Brooks TJ, Hewson R (2013) Pet rats as a source of hantavirus in England and Wales, 2013. Eurosurveillance 18:e57538

    Google Scholar 

  8. Johansson P, Yap G, Low HT, Siew CC, Kek R, Ng LC, Bucht G (2010) Molecular characterization of two hantavirus strains from different rattus species in Singapore. Virol J 7:15

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  9. Kitamura T, Morita C, Komatsu T, Sugiyama K, Arikawa J, Shiga S, Takeda H, Akao Y, Imaizumi K, Oya A, Hashimoto N, Urasawa S (1983) Isolation of virus causing hemorrhagic fever with renal syndrome (HFRS) through a cell culture system. Jpn J Med Sci Biol 36:17–25

    Article  PubMed  CAS  Google Scholar 

  10. Koma T, Yoshimatsu K, Pini N, Safronetz D, Taruishi M, Levis S, Endo R, Shimizu K, Yasuda SP, Ebihara H, Feldmann H, Enria D, Arikawa J (2010) Truncated hantavirus nucleocapsid proteins for serotyping Sin Nombre, Andes, and Laguna Negra hantavirus infections in humans and rodents. J Clin Microbiol 48:1635–1642

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  11. Kruger DH, Schonrich G, Klempa B (2011) Human pathogenic hantaviruses and prevention of infection. Hum Vaccines 7:685–693

    Article  CAS  Google Scholar 

  12. Miettinen MH, Makela SM, Ala-Houhala IO, Huhtala HS, Koobi T, Vaheri AI, Pasternack AI, Porsti IH, Mustonen JT (2009) Tubular proteinuria and glomerular filtration 6 years after puumala hantavirus-induced acute interstitial nephritis. Nephron Clin Pract 112:c115–c120

    Article  PubMed  CAS  Google Scholar 

  13. Miettinen MH, Makela SM, Ala-Houhala IO, Huhtala HS, Hurme MA, Koobi T, Partanen JA, Pasternack AI, Vaheri A, Porsti IH, Mustonen JT (2010) The severity of acute Puumala hantavirus infection does not predict the long-term outcome of patients. Nephron Clin Pract 116:c89–c94

    Article  PubMed  Google Scholar 

  14. Milazzo ML, Cajimat MN, Romo HE, Estrada-Franco JG, Iniguez-Davalos LI, Bradley RD, Fulhorst CF (2012) Geographic distribution of hantaviruses associated with neotomine and sigmodontine rodents, Mexico. Emerg Infect Dis 18:571–576

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  15. Palihawadana P (2009) Research programme for chronic kidney disease of unknown aetiology in Sri Lanka. WER Sri Lanka 36(49):1–4

    Google Scholar 

  16. Pattamadilok S, Lee BH, Kumperasart S, Yoshimatsu K, Okumura M, Nakamura I, Araki K, Khoprasert Y, Dangsupa P, Panlar P, Jandrig B, Kruger DH, Klempa B, Jakel T, Schmidt J, Ulrich R, Kariwa H, Arikawa J (2006) Geographical distribution of hantaviruses in Thailand and potential human health significance of Thailand virus. Am J Trop Med Hyg 75:994–1002

    Article  PubMed  CAS  Google Scholar 

  17. Plyusnin A, Vapalahti O, Lundkvist A (1996) Hantaviruses: genome structure, expression and evolution. J Gen Virol 77:2677–2687

    Article  PubMed  CAS  Google Scholar 

  18. Plyusnina A, Ibrahim IN, Plyusnin A (2009) A newly recognized hantavirus in the Asian house rat (Rattus tanezumi) in Indonesia. J Gen Virol 90:205–209

    Article  PubMed  CAS  Google Scholar 

  19. Reynes JM, Soares JL, Hue T, Bouloy M, Sun S, Kruy SL, Flye Sainte Marie F, Zeller H (2003) Evidence of the presence of Seoul virus in Cambodia. Microbes Infect 5:769–773

    Article  PubMed  Google Scholar 

  20. Reynes JM, Razafindralambo NK, Lacoste V, Olive MM, Barivelo TA, Soarimalala V, Heraud JM, Lavergne A (2014) Anjozorobe hantavirus, a new genetic variant of Thailand virus detected in rodents from Madagascar. Vector Borne Zoonotic Dis 14:212–219

    Article  PubMed  PubMed Central  Google Scholar 

  21. Rippe B (2006) Is there an increased long-term risk of hypertension and renal impairment after Puumala virus-induced nephropathy? Kidney Int 69:1930–1931

    Article  PubMed  CAS  Google Scholar 

  22. Stohwasser R, Raab K, Darai G, Bautz EK (1991) Primary structure of the large (L) RNA segment of nephropathia epidemica virus strain Hallnas B1 coding for the viral RNA polymerase. Virology 183:386–391

    Article  PubMed  CAS  Google Scholar 

  23. Sunil-Chandra NP, Clement J, Maes P, de Silva HJ, van Esbroeck M, van Ranst M (2015) Concomitant leptospirosis-hantavirus co-infection in acute patients hospitalized in Sri Lanka: implications for a potentially worldwide underestimated problem. Epidemiol Infect 143:2081–2093

    Article  PubMed  CAS  Google Scholar 

  24. Vitarana T, Colombage G, Bandaranayake V, Lee HW (1988) Hantavirus disease in Sri Lanka [letter]. Lancet 2:1263

    PubMed  CAS  Google Scholar 

  25. Weaver VM, Fadrowski JJ, Jaar BG (2015) Global dimensions of chronic kidney disease of unknown etiology (CKDu): a modern era environmental and/or occupational nephropathy? BMC Nephrol 16:145

    Article  PubMed  PubMed Central  Google Scholar 

  26. Yoshimatsu K, Arikawa J, Kariwa H (1993) Application of a recombinant baculovirus expressing hantavirus nucleocapsid protein as a diagnostic antigen in IFA test: cross reactivities among 3 serotypes of hantavirus which causes hemorrhagic fever with renal syndrome (HFRS). J Vet Med Sci 55:1047–1050

    Article  PubMed  CAS  Google Scholar 

  27. Yoshimatsu K, Arikawa J (2014) Serological diagnosis with recombinant N antigen for hantavirus infection. Virus Res 187:77–83

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgements

We express sincere thanks to Dr. Akio Koizumi of Kyoto University Graduate School of Medicine for helpful discussions.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to K. Yoshimatsu.

Ethics declarations

Ethical approval

The study was approved by the Institutional Ethical Review Committee, Faculty of Medicine, University of Peradeniya, Sri Lanka (2016/EC/64), and was also approved by the Ethical Review Committee of the Faculty of Medicine, Hokkaido University, Japan (M17-023). Patient/participant consent was obtained prior to recruitment into the study.

Conflict of interest

We declare that we have no conflict of interest.

Additional information

Handling Editor: Hideki Ebihara.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yoshimatsu, K., Gamage, C.D., Sarathkumara, Y.D. et al. Thailand orthohantavirus infection in patients with chronic kidney disease of unknown aetiology in Sri Lanka. Arch Virol 164, 267–271 (2019). https://doi.org/10.1007/s00705-018-4053-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00705-018-4053-x

Navigation