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Salsalate improves glycemic control in patients with newly diagnosed type 2 diabetes

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Abstract

Chronic inflammation contributes to insulin resistance and type 2 diabetes mellitus (T2DM). We investigated whether treatment with salsalate, an anti-inflammatory medication, improves glycemia in a group of newly diagnosed drug-naïve patients with T2DM. The study was a randomized, double-blind, placebo-controlled trial. Diagnosis of T2DM was made within 2 months of enrollment, and participants had not received any anti-glycemic agent. Sixty adults were randomized to receive salsalate (3 g/day) or placebo for 12 weeks. Fasting plasma glucose and insulin, glucose 2 h after 75 g oral glucose, HbA1C, lipid profile, HOMA-IR, and HOMA-B were determined before and after treatment. Salsalate reduced fasting glucose from 6.3 ± 0.2 mmol/l to 5.4 ± 0.2 mmol/l (P < 0.01) and TG from 1.9 ± 0.2 mmol/l to 1.5 ± 0.2 mmol/l (P < 0.03). Fasting insulin levels were increased in the salsalate group from 18.8 ± 1.6 to 21.6 ± 3.9, while they decreased in the placebo group. HbA1c rose in the placebo group from 6.2% ± 0.2 to 7.9% ± 1.1 mmol/mol, but decreased in the intervention group from 6.1% ± 0.5 to 5.6% ± 0.2 mmol/mol (P < 0.04 for between-group comparison). HOMA-IR did not change but HOMA-B increased ~1.7-fold (P = 0.06) in the salsalate group. The results show that salsalate is effective in improving glycemic control in newly diagnosed naïve patients with T2DM. The optimal duration of treatment with salsalate and sustainability of its effect requires further study (IRCT138709011465N1).

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Acknowledgments

No potential conflicts of interest relevant to this article were reported. E.F. wrote the manuscript and researched data. A.A. reviewed/edited the manuscript. H.R. And P.A. reviewed/edited the manuscript. F.I-B. contributed to the discussion and reviewed/edited the manuscript. M.A. researched data and contributed to discussion. The authors thank Majid Abyar, Maryam Zare, Atsa Noruzi and all the staff of the Isfahan Endocrinology and Metabolism Research Center. The authors acknowledge Isfahan University of Medical Sciences for the financial support of this study as a dissertation for E.F.

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Authors and Affiliations

  1. Isfahan Endocrinology and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

    Elham Faghihimani, Ashraf Aminorroaya, Hassan Rezvanian & Masoud Amini

  2. Isfahan University of Medical Sciences, Isfahan, Iran

    Peyman Adibi

  3. Department of Medicine, Case Western Reserve University, Cleveland, OH, USA

    Faramarz Ismail-Beigi

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  1. Elham Faghihimani
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  2. Ashraf Aminorroaya
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Correspondence to Elham Faghihimani.

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Faghihimani, E., Aminorroaya, A., Rezvanian, H. et al. Salsalate improves glycemic control in patients with newly diagnosed type 2 diabetes. Acta Diabetol 50, 537–543 (2013). https://doi.org/10.1007/s00592-011-0329-2

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  • DOI: https://doi.org/10.1007/s00592-011-0329-2

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