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Hidden hazards of HCV transmission

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Abstract

Hepatitis C virus infection is a global health problem that has important epidemiological and clinical consequences. It has been well established that exposure to infected blood is the main risk factor for HCV transmission. However, in 20% of cases the agent transmission occurs by unknown route or in the presence of an unidentified source of infection. Understanding of the epidemiology of HCV is needed to help us define future control and preventive strategies. Herein, we discuss about diagnosis of HCV infection and hepatitis C surveillance in the context of its transmission.

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References

  1. Kao JH, Chen DS (2000) Transmission of hepatitis C virus in Asia: past and present perspectives. J Gastroenterol Hepatol 15(Suppl):E91–E96

    Article  PubMed  Google Scholar 

  2. Hwang SJ, Lee SD, Lu RH (2001) Hepatitis C viral genotype influences the clinical outcome of patients with acute post-transfusion hepatitis C. J Med Virol 65:505–509

    Article  CAS  PubMed  Google Scholar 

  3. Thomas DL, Thio CL, Martin MP, Qi Y, Ge D, O’Huigin C, Kidd J, Kidd K, Khakoo SI, Alexander G, Goedert JJ, Kirk GD, Donfield SM, Rosen HR, Tobler LH, Busch MP, McHutchison JG, Goldstein DB, Carrington M (2009) Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 461(7265):798–801

    Article  CAS  PubMed  Google Scholar 

  4. Tellinghuisen TL, Evans MJ, von Hahn T, You S, Rice CM (2007) Studying Hepatitis C virus: making the best of a bad virus. J Virol 81(17):8853–8867

    Article  CAS  PubMed  Google Scholar 

  5. Alter M (2006) Epidemiology of viral hepatitis and HIV co-infection. J Hepatol 44:6–9

    Article  Google Scholar 

  6. Prati D (2006) Transmission of hepatitis C virus by blood transfusions and other medical procedures: a global review. J Hepatol 45:607–616

    Article  PubMed  Google Scholar 

  7. Schreiber G, Busch M, Kleinman S, Korelitz J (1996) The risk of transfusion-transmitted viral infections. N Eng J Med 26(334):1687–1690

    Google Scholar 

  8. Roy KM, Goldberg D, Taylor A, Mills P (2003) Investigation the source of hepatitis C virus infection among individuals whose route of infection is undefined: a study of ten cases. Scan J Infect Dis 35:326–328

    Article  Google Scholar 

  9. Blackard JT, Shata MT, Shire NJ, Sherman KE (2008) Acute hepatitis C virus infection: a chronic problem. Hepatology 47(1):321–331

    Article  CAS  PubMed  Google Scholar 

  10. Giachetti C, Linnen J, Kolk D, Dockter J, Gillotte-Taylor K, Park M, Ho-Sing-Loy M, McCormick M, Mimms L, McDonough S (2002) Highly sensitive multiplex assay for detection of human immunodeficiency virus type 1 and hepatitis C virus RNA. J Clin Microbiol 7(40):2408–2419

    Article  Google Scholar 

  11. Kolk D, Dockter J, Linnen J, Ho-Sing-Loy M, Gillotte-Taylor K, McDonough S, Mimms L, Giachetti C (2002) Significant closure of the Human Immunodeficiency Virus Type 1 and Hepatitis C Virus preseroconversion detection windows with a transcription-mediated-amplification driven assay. J Clin Microbiol 5(40):1761–1766

    Article  Google Scholar 

  12. Idrees M, Riazuddin S (2008) Frequency distribution of hepatitis C virus genotypes in different geographical regions of Pakistan and their possible routes of transmission. BMC Inf Dis 8:69

    Article  Google Scholar 

  13. Rè V, Gallego S, Farías A, Barbás G, Kremer L, Díaz M, Contigiani M (2008) Hepatitis C and HIV coinfection in central region of Argentina: prevalence, genotype characterization and risk factors. Enferm Infecc Microbiol Clin 26(7):423–425

    Article  PubMed  Google Scholar 

  14. Abou-Setta AM (2004) Transmission risk of hepatitis C virus via semen during assisted reproduction: how reals is it? Hum Reprod 12(19):2711–2717

    Article  Google Scholar 

  15. Thompson S, Boughton C, Dore G (2003) Blood-borne viruses and their survival in the environment: is public concern about community needlestick exposures justified? Aust N Z J Public Health 27(6):602–607

    Article  PubMed  Google Scholar 

  16. Urbanus AT, van de Laar TJ, Stolte IG, Schinkel J, Heijman T, Coutinho RA, Prins M (2009) Hepatitis C virus infections among HIV-infected men who have sex with men: an expanding epidemic. AIDS 23(12):F1–F7

    Article  PubMed  Google Scholar 

  17. Danta M, Brown D, Bhagani S, Pybus OG, Sabin CA, Nelson M, Fischer M, Johnson AM, Dusheiko GM (2007) Recent epidemic of acute hepatitis C virus in HIV-positive men who have sex with men linked to high-risk sexual behaviours. AIDS 21(8):983–991

    Article  PubMed  Google Scholar 

  18. van de Laar TJ, van der Laar Bij AK, Prins M, Bruisten SM, Brinkman K, Ruys TA, van der Meer JT, de Vries HJ, Mulder JW, van Agtmael M, Jurriaans S, Wolthers KC, Coutinho RA (2007) Increase in HCV incidence among men who have sex with men in Amsterdam most likely caused by sexual transmission. J Infect Dis 196(2):230–238

    Article  PubMed  Google Scholar 

  19. Indolfi G, Rest M (2009) Perinatal transmission of hepatitis C virus infection. J Med Virol 81(5):836–843

    Article  PubMed  Google Scholar 

  20. Steininger C, Kundi M, Jatzko G, Kiss H, Lischka A, Holzmann H (2003) Increased risk of mother-to-infant transmission of hepatitis C virus by intrapartum infantile exposure to maternal blood. J Infect Dis 187(3):345–351

    Article  PubMed  Google Scholar 

  21. Mok J, Pembrey L, Tovo P-A, Newell M-L (2004) When does mother to child transmission of hepatitis C virus occur? Arch Dis Child Fetal Neonatal 90:156–160

    Article  Google Scholar 

  22. Kumar RM, Shahul S (1998) Role of breast-feeding in transmission of hepatitis C virus to infants of HCV-infected mothers. J Hepatol 29(2):191–197

    Article  CAS  PubMed  Google Scholar 

  23. Otedo AE, McLigeyo SO, Okoth FA, Kayima JK (2003) Seroprevalence of hepatitis B and C in maintenance dialysis in a public hospital in a developing country. S Afr Med J 93(5):380–384

    CAS  PubMed  Google Scholar 

  24. Sakai N, Tatsuta M, Iishi H, Yano H, Osaka S, Aoki A (2001) Effectiveness of manual cleaning and disinfection of gastroendoscopes with 3% glutaraldehyde for decreasing the risk of transmission of Hepatitis C virus. Am J Gastroenterol 96(6):1803–1806

    Article  CAS  PubMed  Google Scholar 

  25. Center for Disease Control and Prevention (CDC) (2008) Acute hepatitis C virus infections attributed to unsafe injection practices at an endoscopy clinic—Nevada. MMWR 57(19):513–517

    Google Scholar 

  26. Pekova L, Teocharov P, Sakarev A (2007) Clinical course and outcome of a nosocomial outbreak of hepatitis C in a urology ward. J Hosp Inf 67:86–91

    Article  CAS  Google Scholar 

  27. Lédinghen V, Trimoulet P, Cazajous G, Bernard P-H, Schrive M-H, Foucher J, Faure M, Castéra L, Vergniol J, Amouretti M, Fleury H, Couzigou P (2003) Epidemiological and phylogenetic evidence for patient-to-patient hepatitis C virus transmission during sclerotherapy of varicose veins. J Med Virol 76:279–284

    Article  Google Scholar 

  28. Froio N, Nicastri E, Comandini U, Cherubini C, Felicioni R, Solmone M, Di Giulio S, Petrosillo N (2003) Contamination by hepatitis B and C viruses in the dialysis setting. Am J Kidney Dis 42(3):546–550

    Article  PubMed  Google Scholar 

  29. Monsalve-Castillo F, Gomez-Gamboa L (2004) Hepatitis C virus. Iatrogenic and nosocomial transmition? Invest Clin 45(3):193–195

    PubMed  Google Scholar 

  30. Forns X, Martinèz-Bauer E, Feliu A, García-Retortillo M, Martin M, Gay E, Nevasa M, Sanchez-Tapias J, Bruguera M, Rodes J (2005) Nosocomial transmission of HCV in the liver unit of a tertiary care center. Hepatology 41(1):115–122

    Article  PubMed  Google Scholar 

  31. Beltrami EM, Williams IT, Shapiro CN, Chamberland ME (2000) Risk and management of blood-borne infection in health care workers. Clin Microbiol Rev 13(3):385–407

    Article  CAS  PubMed  Google Scholar 

  32. Yazdanpanah Y, De Carli G, Migueres B, Lot F, Campins M, Colombo C, Thomas T, Deuffic-Burban S, Prevot MH, Domart M, Tarantola A, Abiteboul D, Deny P, Pol S, Desenclos JC, Puro V, Bouvet E (2005) Risk factors for hepatitis C virus transmission to health care workers after occupational exposure: European case-control study. Clin Infect Dis 41(1):1423–1430

    Article  CAS  PubMed  Google Scholar 

  33. Raggam RB, Rossmann AM, Salzer HJ, Stauber RE, Kessler HH (2009) Health care worker-to-patient transmission of hepatitis C virus in the health care setting: many questions and few answers. J Clin Virol 45(4):272–275

    Article  PubMed  Google Scholar 

  34. Wang CC, Krantz E, Klarquist J, Krows M, McBride L, Scott E, Shaw-Stiffel T, Weston S, Theide H, Wald A, Rosen H (2007) Acute hepatitis C in a contemporary US cohort: modes of acquisition and factors influencing viral clearance. J Inf Dis 196:1474–1482

    Article  Google Scholar 

  35. Murphy E, Bryzman S, Glynn S, Ameti D, Thomson R, Willian A, Nass C, Ownby H, Screiber G, Kong F, Neal F, Nemo G (2000) Risk factors for hepatitis C virus infection in United States blood donors. Hepatology 31(3):756–762

    Article  CAS  PubMed  Google Scholar 

  36. Raguin G, Rosenthal E, Cacoub P, Veyssier P, Piette JC, Micoud M (1998) Hepatitis C in France: a national survey in the Departments of Internal Medicine and Infectious Diseases. The GERMIVIC (Joint Study Group on Hepatitis C Virus of the French National Society of Internal Medicine and the French Society of Infectious Diseases). Eur J Epidemiol 14(1):545–548

    Article  CAS  PubMed  Google Scholar 

  37. Ferrero MC, Dios PD, Scully C (2005) Transmission of hepatitis C virus by saliva? Oral Dis 11:230–235

    Article  Google Scholar 

  38. Macías J, Palacios R, Claro E, Vargas J, Vergara S, Mira J, Merchante N, Corzo J, Pineda J (2008) High prevalence of hepatitis C virus infection among noninjecting drug users: association with sharing the inhalation implements of crack. Liver Inter 28(6):781–786

    Article  Google Scholar 

  39. van den Berg C, van de Laar T, Kok A, Zuure F, Coutinho R, Prins M (2009) Never injected, but hepatitis C virus-infected: a study among self-declared never-injecting drug users from the Amsterdam Cohort Studies. J Viral Hepat 16:568–577

    Article  PubMed  Google Scholar 

  40. Coppola N, Pisapia R, Marrocco C, Martini S, Vatiero LM, Messina V, Tonziello G, Sagnelli C, Filippini P, Piccinino F, Sagnelli E (2007) Anti-HCV IgG avidity index in acute hepatitis C. J Clin Virol 40(2):110–115

    Article  CAS  PubMed  Google Scholar 

  41. Sagnelli E, Coppola N, Marrocco C, Coviello G, Battaglia M, Messina V, Rossi G, Sagnelli C, Scolastico C, Filippini P (2005) Diagnosis of hepatitis C virus related acute hepatitis by serial determination of IgM anti-HCV titres. J Hepatol 42(5):646–651

    Article  CAS  PubMed  Google Scholar 

  42. Irving W, Salmon D, Boucher C, Hoepelman I (2008) Acute hepatitis C virus infection. EuroSurveill 13(21):1–4 (pii: 18879)

    Google Scholar 

  43. Wasley A, Grytdal S, Gallagher K, Centres for Disease Control, Prevention (CDC) (2008) Surveillance for acute viral hepatitis—United States. MMWR Surveill Summ 57(2):1–24

    PubMed  Google Scholar 

  44. Vento S, Cainelli F, Longhi M (2002) Reactivation of replication of hepatitis B and C viruses after immunosuppressive therapy: an unresolved issue. Lancet Oncol 3(6):333–340

    Article  CAS  PubMed  Google Scholar 

  45. Ennishi D, Yokoyama M, Terui Y, Takeuchi K, Ikeda K, Tanimoto M, Hatake K (2008) Does rituximab really induce hepatitis C virus reactivation? J Clin Oncol 26(28):4695–4696

    Article  PubMed  Google Scholar 

  46. Cardell K, Widell A, Frydén A, Akerling B, Mansson A, Franzén S, Lymer U, Isaksson B (2008) Nosocomial hepatitis C in thoracic surgery unit; retrospective findings generating a prospective study. J Hosp Infect 68:322–328

    CAS  PubMed  Google Scholar 

  47. Molmenti E, Klintmalm G (2000) Hepatitis C recurrence after liver transplantation. Liver Transpl 6(4):413–414

    Article  CAS  PubMed  Google Scholar 

  48. Melon S, Galarraga M, Villar M, Laures A, Boga J, de Oña M, Gomez E (2005) Hepatitis C vírus reactivation in anti-hepatitic C virus-positive renal transplant recipients. Transpl Proc 37(5):2083–2085

    Article  CAS  Google Scholar 

  49. Chen J, Chung J, Kao J, Chen D (2001) Post-partum acute exacerbation of chronic hepatitis in a hepatitis C-carrier mother. J Gastroenterol Hepatol 16(6):705–708

    Article  CAS  PubMed  Google Scholar 

  50. Humar A, Washburn K, Freeman R, Paya C, Mouas H, Alecock E, Razonable R (2007) An assessment of interactions between hepatitis C virus and Herpesvirus reactivation in liver transplant recipients using molecular surveillance. Liver Transpl 13:1422–1427

    Article  PubMed  Google Scholar 

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Correspondence to Robério Amorim de Almeida Pondé.

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Pondé, R. Hidden hazards of HCV transmission. Med Microbiol Immunol 200, 7–11 (2011). https://doi.org/10.1007/s00430-010-0159-9

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  • DOI: https://doi.org/10.1007/s00430-010-0159-9

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