Skip to main content
Log in

Novel treatment of atrophic rhinitis: early results

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

The aim of this randomized control trial, performed at a tertiary referral hospital, was to compare the therapeutic effectiveness of two novel treatment modalities, oral rifampicin and submucosal placentrex injection, in randomly selected patients of primary atrophic rhinitis regarding objective, subjective and histopathological improvement. Patients treated with oral rifampicin showed most promising results regarding objective, subjective and histopathological improvement with maximum disease-free interval on regular follow-up as compared to submucosal placentrex injections.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Sinha SM, Sardana DS, Rajvanshi VS (1977) A nine year review of 273 cases of atrophic rhinitis and its management. J Laryngol Otol 91:591–600

    Article  PubMed  CAS  Google Scholar 

  2. Zohar Y, Talmi YP, Strauss M et al (1990) Ozaena revisited. J Otolaryngol 19:345–349

    PubMed  CAS  Google Scholar 

  3. Dutta SN, Kameshwaran M (2005) The aetiology and management of atrophic rhinitis. J Laryngol Otol 119:843–852

    Google Scholar 

  4. Moore EJ, Kern EB (2001) Atophic rhinitis: a review of 242 cases. Am J Rhinol 15:355–361

    PubMed  CAS  Google Scholar 

  5. Sen HC (1982) The ozaena problem, clinical analysis of atrophic rhinitis in 100 cases. Acta Otolaryngol 93:461–464

    Article  Google Scholar 

  6. Goodman WS, de Souza FM (1973) Atrophic rhinitis. Otolaryngol Clin North Am 6:773–782

    PubMed  CAS  Google Scholar 

  7. Henricksen SD, Gundersen WB (1959) The etiology of ozaena. APMIS 47:380

    Google Scholar 

  8. Singh I, Raizada RM, Chaturvedi VN et al (1994) Atrophic rhinitis: a bacteriological profile. Indian J Otolaryngol 3:154–155

    Google Scholar 

  9. Qizilbash AAH, Daif M (1992) Atrophic rhinitis revisited. Pakistan J Otolaryngol 8:197–199

    Google Scholar 

  10. Brook I (2004) Microbiology and antimicrobial management of sinusitis. Otolaryngol Clin North Am 37:253–266

    Article  PubMed  Google Scholar 

  11. Kuruvilla G, Albert RRA, Job A et al (2006) Pneumocephalus: a rare complication of nasal myiasis. Am J Otolaryngol 27(2):133–135

    Article  PubMed  Google Scholar 

  12. Fouad H, Afifi N, Fatt-hi A et al (1990) Altered cell mediated immunity in atrophic rhinitis. J Laryngol Otol 94:507–514

    Google Scholar 

  13. Chakraborty PD, Bhattacharyya D (2005) Isolation of fibronectin type III like peptide from human placental extract used as wound healer. J Chromatogr B Analyt Technol Biomed Life Sci 818(1):67–73

    Article  PubMed  CAS  Google Scholar 

  14. Singh SM, Gupta SC, Samuel KC et al (1976) Placental extract therapy in atrophic rhinitis. Eye Ear Nose Throat Mon 55:56–61

    Google Scholar 

  15. Dudlev JP (1987) Atrophic rhinitis, antibiotic treatment. Am J Otolaryngol 8:387–390

    Article  Google Scholar 

  16. Nielsen BC, Olinder-Nielsen AM, Malmborg AS (1995) Successful treatment of ozeana with ciprofloxacin. Rhinology 33:57–60

    PubMed  CAS  Google Scholar 

  17. Barbary AS, Yassin A, Fouad H et al (1970) Histopathological and histochemical studies on atrophic rhinitis. J Laryngol Otol 84:1103–1112

    Article  Google Scholar 

  18. Taylor M, Young A (1961) Histological and histochemical studies on atrophic rhinitis. J Laryngol Otol 75:574–589

    PubMed  CAS  Google Scholar 

  19. Mehrotra R, Singhal J, Kawatra M et al (2005) Pre and post-treatment histopathological changes in atrophic rhinitis. Indian J Pathol Microbiol 48(3):310–313

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Abhishek Jaswal.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jaswal, A., Jana, A.K., Sikder, B. et al. Novel treatment of atrophic rhinitis: early results. Eur Arch Otorhinolaryngol 265, 1211–1217 (2008). https://doi.org/10.1007/s00405-008-0629-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00405-008-0629-5

Keywords

Navigation