Skip to main content
Log in

Comparison of reoperation rates, perioperative outcomes in women with endometrial cancer when the standard of care shifts from open surgery to laparoscopy

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

To analyze reoperation rates and perioperative outcomes after long-term follow-up of two surgical approaches in the treatment of endometrial cancer when the standard of care shifts from open surgery to laparoscopy at a university hospital.

Methods

In this retrospective monocenter study a total of 267 patients with endometrial cancer were included; 107 women underwent laparoscopy and 160 laparotomy. All of the patients received total hysterectomy, bilateral salpingo-oophorectomy, and pelvic and para-aortic lymphadenectomy, depending on individual pathological features (e.g. high risk for positive lymph nodes) and the expertise of the surgeon.

Results

Repeat surgery was needed significantly more often in the laparotomy group in comparison with the laparoscopy group (11.9 vs. 0.9 %, respectively; P < 0.001). Hospital stays were longer in the laparotomy group in comparison with laparoscopy (16.2 vs. 9.5 days; P < 0.000001). Postoperative complications were significantly more frequent in the laparotomy group in comparison with laparoscopy (25.0 vs. 10.3 %; P < 0.01). Operating times and preoperative and postoperative hemoglobin differences were similar in the two groups (193.9 vs. 190.6 min, 2.0 vs. 1.8 g/dl). Intraoperative complication rates were similar in the two groups (3.8 vs. 5.6 %).

Conclusions

Laparoscopy is a safe alternative to laparotomy for low risk endometrial cancer patients and offers markedly improved perioperative outcomes with a lower reoperation rate and fewer postoperative complications when the standard of care shifts from open surgery to laparoscopy in a university hospital.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55(2):74–108

    Article  PubMed  Google Scholar 

  2. Wright JD, Barrena Medel NI, Sehouli J, Fujiwara K, Herzog TJ (2012) Contemporary management of endometrial cancer. Lancet 379(9823):1352–1360

    Article  PubMed  Google Scholar 

  3. Janda M, Gebski V, Brand A, Hogg R, Jobling TW, Land R, Manolitsas T, McCartney A, Nascimento M, Neesham D, Nicklin JL, Oehler MK, Otton G, Perrin L, Salfinger S, Hammond I, Leung Y, Walsh T, Sykes P, Ngan H, Garrett A, Laney M, Ng TY, Tam K, Chan K, Wrede CD, Pather S, Simcock B, Farrell R, Obermair A (2010) Quality of life after total laparoscopic hysterectomy versus total abdominal hysterectomy for stage I endometrial cancer (LACE): a randomised trial. Lancet Oncol 11(8):772–780

    Article  PubMed  Google Scholar 

  4. Mourits MJ, Bijen CB, Arts HJ, ter Brugge HG, van der Sijde R, Paulsen L, Wijma J, Bongers MY, Post WJ, van der Zee AG, de Bock GH (2010) Safety of laparoscopy versus laparotomy in early-stage endometrial cancer: a randomised trial. Lancet Oncol 11(8):763–771

    Article  PubMed  Google Scholar 

  5. Walker JL, Piedmonte MR, Spirtos NM, Eisenkop SM, Schlaerth JB, Mannel RS, Spiegel G, Barakat R, Pearl ML, Sharma SK (2009) Laparoscopy compared with laparotomy for comprehensive surgical staging of uterine cancer: Gynecologic Oncology Group Study LAP2. J Clin Oncol 27(32):5331–5336

    Article  PubMed Central  PubMed  Google Scholar 

  6. Mueller A, Thiel F, Lermann J, Oppelt P, Beckmann MW, Renner SP (2010) Feasibility and safety of total laparoscopic hysterectomy (TLH) using the Hohl instrument in nonobese and obese women. J Obstet Gynaecol Res 36(1):159–164

    Article  PubMed  Google Scholar 

  7. Cho YH, Kim DY, Kim JH, Kim YM, Kim YT, Nam JH (2007) Laparoscopic management of early uterine cancer: 10-year experience in Asan Medical Center. Gynecol Oncol 106(3):585–590

    Article  PubMed  Google Scholar 

  8. Wallwiener D, Jonat W, Kreienberg R, Friese K, Diedrich K, Beckmann MW (2009) Atlas der gynäkologischen Operationen, 7th edn. Thieme, Stuttgart

    Google Scholar 

  9. Mueller A, Oppelt P, Binder H, Ackermann S, Beckmann MW (2005) The “Hohl instrument” for optimizing total laparoscopic hysterectomy procedures. J Minim Invasive Gynecol 12:432–435

    Article  PubMed  Google Scholar 

  10. Pecorelli S (2009) Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet 105(2):103–104

    Article  PubMed  Google Scholar 

  11. Perrone AM, Di Marcoberardino B, Rossi M, Pozzati F, Pellegrini A, Procaccini M, Santini D, De Iaco P (2012) Laparoscopic versus laparotomic approach to endometrial cancer. Eur J Gynaecol Oncol 33(4):376–381

    CAS  PubMed  Google Scholar 

  12. Galaal K, Bryant A, Fisher AD, Al-Khaduri M, Kew F, Lopes AD (2012) Laparoscopy versus laparotomy for the management of early stage endometrial cancer. Cochrane Database Syst Rev 9:CD006655

  13. Juhasz-Böss I, Haggag H, Baum S, Kerl S, Rody A, Solomayer E (2012) Laparoscopic and laparotomic approaches for endometrial cancer treatment: a comprehensive review. Arch Gynecol Obstet 286(1):167–172

    Article  PubMed  Google Scholar 

  14. Mueller A, Boosz A, Koch M, Jud S, Faschingbauer F, Schrauder M, Löhberg C, Mehlhorn G, Renner SP, Lux MP, Beckmann MW, Thiel FC (2012) The Hohl instrument for optimizing total laparoscopic hysterectomy: results of more than 500 procedures in a university training center. Arch Gynecol Obstet 285(1):123–127

    Article  PubMed  Google Scholar 

  15. Müller A, Thiel FC, Renner SP, Winkler M, Häberle L, Beckmann MW (2010) Hysterectomy—a comparison of approaches. Dtsch Arztebl Int 107(20):353–359

    PubMed Central  PubMed  Google Scholar 

  16. Mueller A, Renner SP, Haeberle L, Lermann J, Oppelt P, Beckmann MW, Thiel F (2009) Comparison of total laparoscopic hysterectomy (TLH) and laparoscopy-assisted supracervical hysterectomy (LASH) in women with uterine leiomyoma. Eur J Obstet Gynecol Reprod Biol 144(1):76–79

    Article  PubMed  Google Scholar 

  17. Boosz A, Lermann J, Mehlhorn G, Loehberg C, Renner SP, Thiel FC, Schrauder M, Beckmann MW, Mueller A (2011) Comparison of re-operation rates and complication rates after total laparoscopic hysterectomy (TLH) and laparoscopy-assisted supracervical hysterectomy (LASH). Eur J Obstet Gynecol Reprod Biol 158(2):269–273

    Article  PubMed  Google Scholar 

  18. Querleu D, Leblanc E, Cartron G et al (2006) Audit of preoperative and early complications of laparoscopic lymph node dissection in 1000 gynecologic cancer patients. Am J Obstet Gynecol 195:1287–1292

    Article  PubMed  Google Scholar 

  19. Terai Y, Tanaka T, Sasaki H, Kawaguchi H, Fujiwara S, Yoo S, Tanaka Y, Tsunetoh S, Kanemura M, Ohmichi MJ (2014) Total laparoscopic modified radical hysterectomy with lymphadenectomy for endometrial cancer compared with laparotomy. Obstet Gynaecol Res 40(2):570–575

    Article  Google Scholar 

  20. Lu Q, Liu H, Liu C, Wang S, Li S, Guo S, Lu J, Zhang Z (2013) Comparison of laparoscopy and laparotomy for management of endometrial carcinoma: a prospective randomized study with 11-year experience. J Cancer Res Clin Oncol 139(11):1853–1859

    Article  PubMed  Google Scholar 

  21. Tahmasbi Rad M, Wallwiener M, Rom J, Sohn C, Eichbaum M (2013) Learning curve for laparoscopic staging of early and locally advanced cervical and endometrial cancer. Arch Gynecol Obstet 288(3):635–642

    Article  PubMed Central  PubMed  Google Scholar 

  22. De Wilde RL, Rafei A, Herrmann A (2014) Can a lymphadenectomy be avoided in early-stage endometrial adenocarcinoma? Arch Gynecol Obstet [Epub ahead of print]

  23. Tinelli R, Litta P, Meir Y, Surico D, Leo L, Fusco A, Angioni S, Cicinelli E (2014) Advantages of laparoscopy versus laparotomy in extremely obese women (BMI >35) with early-stage endometrial cancer: a multicenter study. Anticancer Res 34(5):2497–2502

    PubMed  Google Scholar 

  24. Rabischong B, Larraín D, Canis M, Le Bouëdec G, Pomel C, Jardon K, Kwiatkowski F, Bourdel N, Achard JL, Dauplat J, Mage G (2011) Long-term follow-up after laparoscopic management of endometrial cancer in the obese: a fifteen-year cohort study. J Minim Invasive Gynecol 18(5):589–596

    Article  PubMed  Google Scholar 

  25. Frey MK, Ihnow SB, Worley MJ Jr, Heyman KP, Kessler R, Slomovitz BM, Holcomb KM (2011) Minimally invasive staging of endometrial cancer is feasible and safe in elderly women. J Minim Invasive Gynecol 18(2):200–204

    Article  PubMed  Google Scholar 

  26. Bogani G, Cromi A, Uccella S, Serati M, Casarin J, Mariani A, Ghezzi F (2014) Laparoscopic staging in women older than 75 years with early-stage endometrial cancer: comparison with open surgical operation. Menopause [Epub ahead of print]

Download references

Conflict of interest

The authors have nothing to disclose.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Alexander Boosz.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Boosz, A., Haeberle, L., Renner, S.P. et al. Comparison of reoperation rates, perioperative outcomes in women with endometrial cancer when the standard of care shifts from open surgery to laparoscopy. Arch Gynecol Obstet 290, 1215–1220 (2014). https://doi.org/10.1007/s00404-014-3347-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-014-3347-9

Keywords

Navigation