Abstract
Porencephaly is defined as an area of focal encephalomalacia that communicates with the ventricular system, giving the appearance of a dilated ventricle. It is assumed that vascular occlusion or an infectious process cause gray and white matter necrosis leading to cyst formation in the cerebral parenchyma. Possible etiology of porencephaly includes intracerebral thrombosis, intracranial hemorrhage and fetal infection. We report the first antenatal diagnosis of porencephaly, which apparently resulted from maternal carbon monoxide poisoning.
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Pasternak JF, Mantovani JF, Volpe JJ (1981) Porencephaly from periventricular intracerebral hemorrhage in a premature infant. Am J Dis Child 134:673–675
Eller KM, Kuller JA (1995) Fetal porencephaly: a review of etiology, diagnosis, and prognosis. Obstet Gynecol Surv 50:684–687. doi:10.1097/00006254-199509000-00023
Gross H, Simanyu M (eds) (1977) Handbook of clinical neurology. Elsevier, Amsterdam
Moinuddin A, McKinstry RC, Martin KA, Neil JJ (2003) Intracranial hemorrhage progressing to porencephaly as a result of congenitally acquired cytomegalovirus infection—an illustrative report. Prenat Diagn 23:797–800. doi:10.1002/pd.688
Viljoen DL (1995) Porencephaly and transverse limb defects following severe maternal trauma in early pregnancy. Clin Dysmorphol 4:75–78. doi:10.1097/00019605-199501000-00011
Sharma AK, Phadke S (1991) Porencephaly: a possible complication of chorion villus sampling? Indian Pediatr 28:1061–1063
Eller KM, Kuller JA (1995) Porencephaly secondary to fetal trauma during amniocentesis. Obstet Gynecol 85:865–867. doi:10.1016/0029-7844(94)00315-5
Debus O, Koch HG, Kurlemann G, Strater R, Vielhaber H, Weber P et al (1998) Leiden and genetic defects of thrombophilia in childhood porencephaly. Arch Dis Child Fetal Neonatal Ed 78:F121–F124
Mancini GM, de Coo IF, Lequin MH, Arts WF (2004) Hereditary porencephaly: clinical and MRI findings in two Dutch families. Eur J Paediatr Neurol 8:45–54. doi:10.1016/j.ejpn.2003.10.002
Lubinsky MS (1997) Hypothesis: septo-optic dysplasia is a vascular disruption sequence. Am J Med Genet 69:235–236. doi:10.1002/(SICI)1096-8628(19970331)69:3<235::AID-AJMG4>3.0.CO;2-K
Hennekam RC (1994) Scalp lipomas and cerebral malformations: overlap between encephalocraniocutaneous lipomatosis and oculocerebrocutaneous syndrome. Clin Dysmorphol 3:87–89. doi:10.1097/00019605-199401000-00013
Aubard Y, Magne I (2000) Carbon monoxide poisoning in pregnancy. BJOG 107:833–838. doi:10.1111/j.1471-0528.2000.tb11078.x
Elkharrat D, Raphael JC, Korach JM et al (1991) Acute carbon monoxide intoxication and hyperbaric oxygen in pregnancy. Intensive Care Med 17:289–292. doi:10.1007/BF01713940
Ginsberg MD, Myers RE (1976) Fetal brain injury after maternal carbon monoxide intoxication. Clinical and neuropathologic aspects. Neurology 26:15–23
Woody RC, Brewster MA (1990) Telencephalic dysgenesis associated with presumptive maternal carbon monoxide intoxication in the first trimester of pregnancy. J Clin Toxicol 28:467–475
Beaudoing A (1969) Gachon 3, Butin LP, Bost M. Les consCquences fcetales de l’intoxication oxycarbonte de la mtre. Pidiatrie 24:539–553
Bailey LJ, Johnston MC, Billet J (1995) Effects of carbon monoxide and hypoxia on cleft lip in A/J mice. Cleft Palate Craniofac J 32:14–19. doi:10.1597/1545-1569(1995)032<0014:EOCMAH>2.3.CO;2
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Gul, A., Gungorduk, K., Yıldırım, G. et al. Prenatal diagnosis of porencephaly secondary to maternal carbon monoxide poisoning. Arch Gynecol Obstet 279, 697–700 (2009). https://doi.org/10.1007/s00404-008-0776-3
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DOI: https://doi.org/10.1007/s00404-008-0776-3