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Ätiologie und Management der Gicht

The etiology and management of gout

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Zusammenfassung

Gicht ist eine durch intra- und/oder periartikuläre Einlagerung von Mononatriumuratkristallen verursachte entzündliche Form der Arthritis. Auch Harnsteine können sich bilden, sie kommen aber seltener vor als eine Arthritis. In der Regel manifestiert sich eine Gicht durch rezidivierende Gelenkentzündungen, die mit der Zeit zur Bildung von Tophi und zur Zerstörung des Gelenks führen. Im letzten Jahrzehnt sind signifikante Fortschritte erreicht worden: bei der Erforschung sowohl epidemiologischer als auch genetischer Aspekte von Gicht und Hyperurikämie, aber auch bei der Aufklärung pathogenetischer Mechanismen und bei der Erweiterung des Behandlungsspektrums. Erkenntnisse zur Schlüsselrolle des Interleukin 1 (IL-1) bieten neue therapeutische Perspektiven. Dennoch ist das Management häufig suboptimal: Viele Gichtpatienten werden nicht adäquat behandelt, viele vertragen die bisher verfügbaren Substanzen nicht. Innovative Substanzen stellen interessante neue Optionen dar für Patienten mit schwer zu behandelnder Gicht.

Der englische Originaltext des Beitrags steht auf SpringerLink (unter „Supplemental“) zur Verfügung.

Abstract

Gout is an inflammatory arthritis caused by monosodium urate (MSU) crystal deposits in and around the joint. The formation of urinary calculi can also occur in gout, but are less common than arthritis. Gout usually presents with recurrent episodes of joint inflammation, which over time lead to tophus formation and joint destruction. In the last decade, significant advances have been made regarding not only the epidemiology and genetics of gout and hyperuricemia but also the mechanisms of inflammation and treatment of gout. In addition, knowledge concerning the key role of interleukin 1 (IL-1) has provided new therapeutic perspectives. However, the current management of gout is often suboptimal, with many Patienten either not receiving adequate treatment or being unable to tolerate existing treatments. New therapeutic agents provide interesting new options for Patienten with difficult-to-treat gouty arthritis.

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  1. Department of Rheumatology, Centre Hospitalier Universitaire Vaudois, 1011, Lausanne, Suisse

    B. Pazár Maldonado & A. So

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  1. B. Pazár Maldonado
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  2. A. So
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Pazár Maldonado, B., So, A. Ätiologie und Management der Gicht. Z. Rheumatol. 71, 127–137 (2012). https://doi.org/10.1007/s00393-012-0961-4

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