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Nephrotic syndrome as a clinical manifestation of systemic sclerosis

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Abstract

We have described the unusual case of coexistence of membranous nephropathy resulting in nephrotic syndrome with systemic sclerosis. A 60-year-old patient was admitted to the Department of Nephrology with marked proteinuria and oedema. The renal biopsy specimen disclosed the features characteristic of membranous glomerulonephritis. The patient was treated with chlorambucil for 1 month followed by prednisone for 1 month. However, her condition still did not improve. Therefore, the other causes of nephrotic syndrome were investigated. Once anti-Scl-70 antibody was detected the patient was transferred to the Department of Rheumatology and Connective Tissue Diseases. Physical examination revealed Raynaud phenomenon, sclerodactylia, thickened skin of the chest and back. The patient was diagnosed with diffuse systemic sclerosis. The cyclophosphamide therapy was instituted and the patient’s condition improved.

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References

  1. Majdan M, Parada-Turska J, Suszek D (2004) Renal involvement in rheumatic diseases. Polskie Archiwum Medycyny Wewnętrznej 112:167–172

    Google Scholar 

  2. Balck C, Denton CP (1998) Scleroderma-systemic sclerosis. In: Davison AM, Cameron JS, Grunfeld JP (eds) Oxford textbook of clinical nephrology. Oxford University Press, New York, pp 961

  3. Traub YM, Shapiro AP, Rodnan GP, Medsger TA, McDonald RH, Steen VD, Osial TA, Tolchin SF (1983) Hypertension and renal failure (scleroderma renal crisis) in progressive systemic sclerosis. Review of a 25-year experience with 68 cases. Medicine 62:335–352

    CAS  Google Scholar 

  4. Steen VD, Syzd A, Johnson JP, Greenberg A, Medsger TA (2005) Kidney disease other than renal crisis in patients with diffuse scleroderma. J Rheumatol 32:649–655

    PubMed  Google Scholar 

  5. Simms RW, Korn JH (2001) Systemic sclerosis; the spectrum immunopathogenesis clinical features, and treatment. In: Adu D, Emery P, Madaio M (eds) Rheumatology and the kidney. Oxford University Press, New York, pp 275

  6. Palma A, Sanchez-Palenica A, Armas JR, Milan JA, Fernandez-Sanz J, Llach F (1981) Progressive systemic sclerosis and nephrotic syndrome. Arch Intern Med 141:520–521

    Article  PubMed  CAS  Google Scholar 

  7. Kobayashi Y, Muraoka M, Tojo T (1977) Progressive systemie sclerosis sine scleroderma with nephrotic syndrome and suspected renal tubular acidosis. Nippon Naika Gakkai Zasshi 66:186–189

    Google Scholar 

  8. Bourne FM, Howell DA, Root HS (1960) Renal and cerebral scleroderma. Can Med Assoc J 82:881–886

    PubMed  CAS  Google Scholar 

  9. Rihova Z, Honsova E, Merta M, Jancova E, Rysava R, Reiterova J, Zabka J, Tesar V (2005) Secondary membranous nephropathy—one center experience. Ren Fail 27:397–402

    PubMed  Google Scholar 

  10. Jefferson JA Couser WG (2003) Therapy of membranous nephropathy associated with malignancy and secondary causes. Semin Nephrol 23:400–405

    Article  Google Scholar 

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Correspondence to Ewa Wielosz.

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Wielosz, E., Majdan, M., Suszek, D. et al. Nephrotic syndrome as a clinical manifestation of systemic sclerosis. Rheumatol Int 27, 1087–1089 (2007). https://doi.org/10.1007/s00296-007-0340-7

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  • DOI: https://doi.org/10.1007/s00296-007-0340-7

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