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Regions of High Wall Stress Can Predict the Future Location of Rupture of Abdominal Aortic Aneurysm

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Abstract

Predicting the wall stress in abdominal aortic aneurysm (AAA) using computational modeling may be a useful adjunct to traditional clinical parameters that indicate the risk of rupture. Maximum diameter has been shown to have many limitations, and using current technology it is possible to provide a patient-specific computational risk assessment using routinely acquired medical images. We present a case of AAA rupture where the exact rupture point was clearly visible on the computed tomography (CT) images. A blind computational study based on CT scans acquired 4 months earlier predicted elevated wall stresses in the same region that later experienced rupture.

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References

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Acknowledgments

This work was funded by The University of Western Australia Research Fellowship and the UWA ECM Research Development Award. The authors are grateful for assistance from staff in the Imaging Department of Fremantle Hospital.

Conflict of interest

Barry Doyle, Timothy McGloughlin, Karol Miller, Janet Powell, and Paul Norman have no conflict of interest to declare.

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Authors and Affiliations

  1. Intelligent Systems for Medicine Laboratory, School of Mechanical and Chemical Engineering, The University of Western Australia, 35 Stirling Highway, Perth, WA, Australia

    Barry J. Doyle & Karol Miller

  2. Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UK

    Barry J. Doyle

  3. Department of Mechanical, Aeronautical and Biomedical Engineering, Centre for Applied Biomedical Engineering Research, and the Materials and Surface Science Institute, University of Limerick, Limerick, Ireland

    Timothy M. McGloughlin

  4. Institute of Mechanics and Advanced Materials, School of Engineering, Cardiff University, Cardiff, UK

    Karol Miller

  5. Vascular Surgery Research Group, Imperial College, Charing Cross Campus, London, UK

    Janet T. Powell

  6. School of Surgery, Fremantle Hospital, The University of Western Australia, Fremantle, WA, Australia

    Paul E. Norman

Authors
  1. Barry J. Doyle
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  2. Timothy M. McGloughlin
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  3. Karol Miller
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  4. Janet T. Powell
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  5. Paul E. Norman
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Corresponding author

Correspondence to Barry J. Doyle.

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Doyle, B.J., McGloughlin, T.M., Miller, K. et al. Regions of High Wall Stress Can Predict the Future Location of Rupture of Abdominal Aortic Aneurysm. Cardiovasc Intervent Radiol 37, 815–818 (2014). https://doi.org/10.1007/s00270-014-0864-7

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  • DOI: https://doi.org/10.1007/s00270-014-0864-7

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