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Effects of propiverine hydrochloride, an anticholinergic agent, on urethral continence mechanisms and plasma catecholamine concentration in rats

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Abstract

Introduction and hypothesis

Anticholinergics are used to treat overactive bladder. Anticholinergic agents such as propiverine hydrochloride reportedly increase plasma catecholamine levels in rats. It is also known that active urethral closure mechanisms prevents stress urinary incontinence (SUI), which is enhanced by central and peripheral noradrenergic system activation. Therefore, we examined the influence of propiverine hydrochloride on urethral anti-incontinence function in rats.

Methods

Adult female rats were divided into propiverine and vehicle-treated groups. The propiverine group was given propiverine orally once a day for 2 weeks, after which urethral function and plasma concentrations of catecholamine (dopamine, norepinephrine, epinephrine) were tested.

Results

Urethral baseline pressure measured by a microtransducer-tipped urethral catheter and leak-point pressure during passive intravesical pressure elevation were significantly increased in the propiverine group compared with the vehicle group. Plasma norepinephrine and epinephrine levels in the propiverine group were also significantly increased.

Conclusions

Propiverine treatment that increases plasma catecholamine levels could contribute to improvement of SUI conditions by increasing urethral resistance.

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Abbreviations

SUI:

Stress urinary incontinence

A-URS:

Amplitude of urethral responses during sneezing

UBP:

Urethral baseline pressure

LPP:

Leak-point pressure

MUI:

Mixed urinary incontinence

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Conflicts of interest

M Nanri and M Kiniwa are both employees of TAIHO Phamaceutical Co.

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Authors and Affiliations

  1. Department of Urology, University of Pittsburgh School of Medicine, Suite 700, Kaufmann Medical Bldg., 3471 Fifth Ave, Pittsburgh, PA, 15213, USA

    Takeya Kitta, Vikas Tyagi & Naoki Yoshimura

  2. Department of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, 060-8638, Japan

    Takeya Kitta & Katsuya Nonomura

  3. TAIHO Phamaceutical Co., Ltd., Tokyo, Japan

    Masato Nanri & Mamoru Kiniwa

Authors
  1. Takeya Kitta
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  2. Vikas Tyagi
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  3. Masato Nanri
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  4. Mamoru Kiniwa
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  5. Katsuya Nonomura
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  6. Naoki Yoshimura
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Corresponding author

Correspondence to Naoki Yoshimura.

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Kitta, T., Tyagi, V., Nanri, M. et al. Effects of propiverine hydrochloride, an anticholinergic agent, on urethral continence mechanisms and plasma catecholamine concentration in rats. Int Urogynecol J 24, 683–688 (2013). https://doi.org/10.1007/s00192-012-1924-7

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  • DOI: https://doi.org/10.1007/s00192-012-1924-7

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