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Das Histaminintoleranzsyndrom

Seine Bedeutung für die HNO-Heilkunde

Histamine intolerance syndrome

Its significance for ENT medicine

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Zusammenfassung

Das Histaminintoleranzsyndrom ähnelt in der Symptomatik der allergischen, IgE-vermittelten Reaktion. Die betroffenen Patienten, meist Frauen mittleren Alters, leiden z. B. unter Kopfschmerzen und Fließschnupfen, insbesondere nach dem Verzehr histaminreicher Nahrungsmittel, dem Genuss alkoholischer Getränke oder der Einnahme bestimmter Medikamente. Neben diesen Symptomen sind auch lebensbedrohliche anaphylaktische Reaktionen zu beobachten. Der vorliegende Artikel beschreibt die biochemischen Prozesse und zellulären Hintergründe des HIS und zeigt die diagnostischen und therapeutischen Verfahren in der HNO-Heilkunde auf. Unser Ziel ist es, die Aufmerksamkeit auf dieses oft unerkannte Krankheitsbild zu lenken und zu einem vertieften immunologischen Verständnis beizutragen.

Abstract

The symptoms of histamine intolerance are similar to those of the IgE-mediated allergic immune response. Patients affected by this disease, mostly middle-aged women, suffer from conditions such as headaches and rhinitis, particularly after consuming histamine-rich foods, indulging in alcoholic beverages, or taking certain pharmaceuticals. Moreover, life-threatening anaphylactic reactions can be observed with this syndrome. This article describes the biochemical processes and cellular background of histamine intolerance syndrome and discusses the diagnostic and therapeutic procedures within otorhinolaryngology. It is our goal to direct attention to this often unrecognized clinical picture and to contribute to increased immunologic knowledge of this disease.

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Literatur

  1. Akin C, Soto D, Brittain E et al. (2007) Tryptase haplotype in mastocytosis: relationship to disease variant and diagnostic utility of total tryptase levels. Clin Immunol 123: 268–271

    Article  PubMed  CAS  Google Scholar 

  2. Bachert C, Borchard U, Wedi B et al. (2003) Leitlinie der DGAI zur allergischen Rhinokonjunktivitis. Allergologie 26: 147–162

    Google Scholar 

  3. Bachert C, Lange B (2002) Desloratadin: Profil eines modernen Antihistaminikums. Allergologie 25: 24–33

    Google Scholar 

  4. Bodmer S, Imark C, Kneubuhl M (1999) Biogenic amines in foods: histamine and food processing. Inflamm Res 48: 296–300

    Article  PubMed  CAS  Google Scholar 

  5. Dale HH, Laidlaw PP (1910) The physiological action of beta-iminazolylethylamine. J Physiol 41: 318–344

    PubMed  CAS  Google Scholar 

  6. Garcia-Martin E, Ayuso P, Martinez C, Agundez JA (2007) Improved analytical sensitivity reveals the occurrence of gender-related variability in diamine oxidase enzyme activity in healthy individuals. Clin Biochem 40: 1339–1341

    Article  PubMed  CAS  Google Scholar 

  7. Izquierdo-Pulido M, Albalá-Hurtado S, Mariné-Font A, Vidal-Carou MC (1996) Biogenic amines in Spanish beers: differences among breweries. Z Lebensm Unters Forsch 203: 507–511

    Article  PubMed  CAS  Google Scholar 

  8. Jarisch R (2004) Histamin-Intoleranz. Ärztemagazin 8: 1–4

    Google Scholar 

  9. Jarisch R (2004) Histamin-Intoleranz. Histamin und Seekrankheit. Thieme, Stuttgart

  10. Jarisch R, Wantke F (1996) Wine and headache. Int Arch Allergy Immunol 110: 7–12

    Article  PubMed  CAS  Google Scholar 

  11. Kemp SF, Lockey RF (2002) Anaphylaxis: a review of causes and mechanisms. J Allergy Clin Immunol 110: 341–348

    Article  PubMed  CAS  Google Scholar 

  12. Klimek L (2007) Anaphylaxie – Status Quo der Versorgung von Patienten. Expertenforum Allergie, Allergopharma, Reinbek

  13. Klimek L, Reske-Kunz AB, Saloga J (1999) Die spezifische Hyposensibilisierung, Immuntherapie. Thieme, Stuttgart

  14. Klocker J, Perkmann R, Klein-Weigel P et al. (2004) Continuous administration of heparin in patients with deep vein thrombosis can increase plasma levels of diamine oxidase. Vascul Pharmacol 40: 293–300

    Article  PubMed  CAS  Google Scholar 

  15. Maintz L, Bieber T, Novak N (2006) Die verschiedenen Gesichter der Histaminintoleranz. Dtsch Ärztebl 103: 3477–3483

    Google Scholar 

  16. Maintz L, Novak N (2007) Histamine and histamine intolerance. Am J Clin Nutr 85: 1185–1196

    PubMed  CAS  Google Scholar 

  17. Ring J, Brockow K, Duda D et al. (2007) Leitlinie: Akuttherapie anaphylaktischer Reaktionen. Allergo J 16: 420–434

    Google Scholar 

  18. Ring J, Darsow U (2002) Idiopathic anaphylaxis. Curr Allergy Asthma Rep 2: 40–45

    Article  PubMed  Google Scholar 

  19. Ring J, Messmer K (1977) Incidence and severity of anaphylactoid reactions to colloid volume substitutes. Lancet 1: 466–469

    Article  PubMed  CAS  Google Scholar 

  20. Sattler J, Lorenz W (1990) Intestinal diamine oxidases and enteral-induced histaminosis: studies on three prognostic variables in an epidemiological model. J Neural Transm Suppl 32: 291–314

    PubMed  CAS  Google Scholar 

  21. Silla Santos MH (1996) Biogenic amines: their importance in foods. Int J Food Microbiol 29: 213–231

    Article  Google Scholar 

  22. Steinbrecher I, Jarisch R (2005) Histamin und Kopfschmerz. (Histamine and headache). Allergologie 28: 84–91

    Google Scholar 

  23. Vally H, Thompson PJ (2003) Allergic and asthmatic reactions to alcoholic drinks. Addict Biol 8: 3–11

    Article  PubMed  CAS  Google Scholar 

  24. Vlieg-Boerstra BJ, Heide S van der, Oude Elberink JN et al. (2005) Mastocytosis and adverse reactions to biogenic amines and histamine-releasing foods: What is the evidence? Neth J Med 63: 244–249

    PubMed  CAS  Google Scholar 

  25. Wantke F, Gotz M, Jarisch R (1993) Histamine-free diet: treatment of choice for histamine-induced food intolerance and supporting treatment for chronic headaches. Clin Exp Allergy 23: 982–985

    Article  PubMed  CAS  Google Scholar 

  26. Wantke F, Hemmer W, Focke M et al. (1999) The red wine maximization test: drinking histamine rich wine induces a transient increase in plasma diamine oxidase activity in healthy volunteers. Inflamm Res 48: 169–170

    Article  PubMed  CAS  Google Scholar 

  27. Weiss S, Robb GP, Ellis LB (1932) The systematic effects of histamine in man. Arch Intern Med 49: 360–396

    Google Scholar 

  28. Wohrl S, Hemmer W, Focke M et al. (2004) Histamine intolerance-like symptoms in healthy volunteers after oral provocation with liquid histamine. Allergy Asthma Proc 25: 305–311

    PubMed  Google Scholar 

  29. Zajonc TP, Roland PS (2006) Vertigo and motion sickness. Part II: Pharmacologic treatment. Ear Nose Throat J 85: 25–35

    PubMed  Google Scholar 

  30. Zimatkin SM, Anichtchik OV (1999) Alcohol-histamine interactions. Alcohol Alcohol 34: 141–147

    PubMed  CAS  Google Scholar 

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  1. Zentrum für Rhinologie und Allergologie, An den Quellen 10, 65183, Wiesbaden, Deutschland

    I. Böttcher &  L. Klimek

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  1. I. Böttcher
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  2. L. Klimek
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Correspondence to L. Klimek.

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Böttcher, I., Klimek, L. Das Histaminintoleranzsyndrom. HNO 56, 776–783 (2008). https://doi.org/10.1007/s00106-008-1793-z

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  • DOI: https://doi.org/10.1007/s00106-008-1793-z

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